FB2022_03, released June 9, 2022

Allele: Dmel\CblL.mPR.UAS

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General Information
Symbol
Dmel\CblL.mPR.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0258206
Feature type
allele
Associated gene
Dmel\Cbl
Associated Insertion(s)
Carried in Construct
P{UAS-Cbl.L.mPR}
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Wang and Pai, 2011)
in vitro construct - amino acid replacement
(Wang and Pai, 2011)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-Cbl.L.mPR}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of the long Cbl isoform carrying a modified PPLPPR motif, where the first and fifth prolines are replaced with alanines (APLPAR).

      (Wang and Pai, 2011)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      Cbl
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of CblL.mPR.Scer\UAS in the follicle cells under the control of Scer\GAL4EQ1 results in a ventralised eggshell phenotype. Eggs display disrupted dorsal appendage morphology, and fusing or loss of dorsal appendages is observed.

      (Wang and Pai, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      CblL.mPR.UAS, Scer\GAL4EQ1 has dorsal appendage phenotype, non-suppressible by drk[+]/drke0A/drke0A

      (Wang and Pai, 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      drke0A/+ fails to suppresses the ventralised egg shell phenotype observed when CblL.mPR.Scer\UAS is expressed in follicle cells under the control of Scer\GAL4EQ1.

      (Wang and Pai, 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CblL.mPR.Scer\UAS
      CblL.mPR.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)