FB2026_02 , released June 18, 2026
Allele: Dmel\trioGEF1mu.UAS
Open Close
General Information
Symbol
Dmel\trioGEF1mu.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0258381
Feature type
allele
Associated gene
Dmel\trio
Associated Insertion(s)
Carried in Construct
P{UAS-trio.GEF1mu}
Key Links
Transgenic product class
missense_variant
(Song and Giniger, 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Song and Giniger, 2011)
Mutagen
in vitro construct
(Song and Giniger, 2011)
Progenitor genotype
Carried in construct
P{UAS-trio.GEF1mu}
Cytology
Description

UAS regulatory sequences drive expression of mutated trio sequences. The first guanine nucleotide exchange factor domain is mutated.

(Song and Giniger, 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
trio
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pan-neuronal expression of trioGEF1mu.Scer\UAS under the control of Scer\GAL4elav-C155 does not produce any dominant axon patterning defects in a wild-type background.

      (Song and Giniger, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4elav-C155/trioGEF1mu.UAS is a suppressor of abnormal neuroanatomy | heat sensitive phenotype of Nl1N-ts1, trio123.4/trio[+]

      (Song and Giniger, 2011)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4elav-C155/trioGEF1mu.UAS is a non-suppressor of abnormal neuroanatomy | heat sensitive phenotype of Nl1N-ts1, trio123.4/trio[+]

      (Song and Giniger, 2011)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4elav-C155/trioGEF1mu.UAS is a non-suppressor of larval intersegmental nerve | heat sensitive phenotype of Nl1N-ts1, trio123.4/trio[+]

      (Song and Giniger, 2011)

      Scer\GAL4elav-C155/trioGEF1mu.UAS is a non-suppressor of larval intersegmental nerve branch ISNb of A1-7 | heat sensitive phenotype of Nl1N-ts1, trio123.4/trio[+]

      (Song and Giniger, 2011)

      Scer\GAL4elav-C155/trioGEF1mu.UAS is a non-suppressor of larval segmental nerve branch SNa of A1-7 | heat sensitive phenotype of Nl1N-ts1, trio123.4/trio[+]

      (Song and Giniger, 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pan-neuronal expression of trioGEF1mu.Scer\UAS in a Nl1N-ts1; trio123.4/+ background (under the control of Scer\GAL4elav-C155) does not restore the ability of ISNb axons to enter the ventrolateral muscle field.

      (Song and Giniger, 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      trioGEF1mu.Scer\UAS
      trioGEF1mu.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)