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General Information
Symbol
Dmel\trio123.4
Species
D. melanogaster
Name
FlyBase ID
FBal0146746
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

trio8/trio123.4 embryos display stalling of the ISNb motor nerve at the junction of muscles 6 and 13 with failure to innervate muscle 12 in >65% of hemisegments examined. trio123.4 heterozygous show the stalling phenotype (observed in 16% of examined hemisegments).

trio1/trio123.4 mutants display a specific axonal defect in ISNb, 'stalling' in the middle of the target field.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Nl1N-ts1, trio123.4/trio[+] has abnormal neuroanatomy | heat sensitive phenotype, enhanceable by Scer\GAL4elav-C155/trioUAS.cBa

Suppressed by
Statement
Reference

Nl1N-ts1, trio123.4/trio[+] has abnormal neuroanatomy | heat sensitive phenotype, suppressible by Scer\GAL4elav-C155/trioGEF1mu.UAS

NOT suppressed by
Statement
Reference

Nl1N-ts1, trio123.4/trio[+] has abnormal neuroanatomy | heat sensitive phenotype, non-suppressible by Scer\GAL4elav-C155/trioGEF1mu.UAS

Suppressor of
Statement
Reference

trio123.4/trio[+] is a suppressor of abnormal neuroanatomy | heat sensitive phenotype of Nl1N-ts1

Phenotype Manifest In
Enhanced by
Suppressed by
NOT suppressed by
Enhancer of
Suppressor of
Statement
Reference

trio123.4/trio[+] is a suppressor of larval intersegmental nerve | heat sensitive phenotype of Nl1N-ts1

trio123.4/trio[+] is a suppressor of larval intersegmental nerve branch ISNb of A1-7 | heat sensitive phenotype of Nl1N-ts1

trio123.4/trio[+] is a suppressor | partially of larval intersegmental nerve | heat sensitive phenotype of Nl1N-ts1

Additional Comments
Genetic Interactions
Statement
Reference

SCARΔ37/+;trio123.4/+ double heterozygous embryos show stalling of the ISNb motor nerve at the junction of muscles 6 and 13 with failure to innervate muscle 12 in 51% of examined hemisegments - a strongly increased penetrance compared to either of the single heterozygotes.

The stalling of the ISNb motor nerve at the junction of muscles 6 and 13 with failure to innervate muscle 12 characteristic for trio8/trio123.4 mutant embryos is not suppressed by Scer\GAL4elav.PU-driven expression of AblScer\UAS.cFa in the mutant background.

A trio123.4 heterozygous background significantly restores the ability of ISNb axons to enter the ventrolateral muscle field in Nl1N-ts1 mutants. This suppression is reverted upon pan-neural expression of trioScer\UAS.cBa under the control of Scer\GAL4elav-C155.

Pan-neuronal expression of trioGEF1mu.Scer\UAS in a Nl1N-ts1; trio123.4/+ background (under the control of Scer\GAL4elav-C155) does not restore the ability of ISNb axons to enter the ventrolateral muscle field.

Pan-neuronal expression of trioGEF2mu.Scer\UAS in a Nl1N-ts1; trio123.4/+ background (under the control of Scer\GAL4elav-C155) restores the ability of ISNb axons to enter the ventrolateral muscle field.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)