FB2026_02 , released June 18, 2026
Allele: Dmel\krzd1
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General Information
Symbol
Dmel\krzd1
Species
D. melanogaster
Name
FlyBase ID
FBal0258538
Feature type
allele
Associated gene
Dmel\krz
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Molnar et al., 2011)
Mutagen
FLPase
(Molnar et al., 2011)
Progenitor genotype
PBac{RB}krze03507
(Molnar et al., 2011)
PBac{RB}mode00739
(Molnar et al., 2011)
Caused by aberration
Df(3R)krz
Cytology
Description

A 3.8 kb deletion removing the entire coding part of the krz transcription unit and part of the 5' untranslated region of mod.

(Molnar et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:32,048,516..32,052,475 [-]
Comment:

A 3.8 kb deletion of krz resulting from FLP-catalyzed recombination using the FRT-containing transposons PBac{RB}mode00739 and PBac{RB}krze03507.

(Molnar et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Clones of cell homozygous for krzd1 cause reduced wing size and incorrect wing folding.

      Homozygous krzd1 and trans-heterozygous krzd1/krzS047819 mutant animals survive until the third larval instar, where they become immobile and flaccid and form melanotic tumors. The imaginal discs of these mutant larvae are very reduced in size and display increased cell death.

      Expression of krzScer\UAS.cMa in the central nervous system under the control of Scer\GAL4wor.PA rescues the lethality of krzd1/krzS047819. The surviving flies are sterile and display slightly folded wings. Wing discs in rescued larvae have a normal appearance.

      (Molnar et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      krzS047819/krzd1 is partially rescued by krzUAS.cMa/Scer\GAL4wor.PA

      (Molnar et al., 2011)
      Comments

      Expression of krzScer\UAS.cMa in the central nervous system under the control of Scer\GAL4wor.PA rescues the lethality of krzd1/krzS047819. The surviving flies are sterile and display slightly folded wings. Wing discs in rescued larvae have a normal appearance.

      (Molnar et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Df(3R)krz
      (Molnar et al., 2011)
      krzd1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)