FlyBase Allele Report: Dmel\RagC-D[Q99L.UAS]

General Information

Symbol

Dmel\RagC-D^Q99L.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0258714

Feature type

allele

Associated gene

Dmel\RagC-D

Associated Insertion(s)

Carried in Construct

P{UAS-RagC-D.Q99L}

Also Known As

UAS-RagC^Q99L

Key Links

Transgenic product class

missense_variant

(Goraksha-Hicks, 2011.5.13)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Goraksha-Hicks, 2011.5.13)

Mutagen

in vitro construct

(Goraksha-Hicks, 2011.5.13)

Progenitor genotype

Carried in construct

P{UAS-RagC-D.Q99L}

Cytology

Description

UAS drives expression of RagC containing a Q99L substitution which creates a constitutively active mutant - the RagC protein always stays in the GTP bound form.

(Goraksha-Hicks, 2011.5.13)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

RagC-D

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size, with Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

decreased cell number, with Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

Phenotype Manifest In

wing, with Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

Detailed Description

Statement

Reference

Expression of RagC^{Q99L.Scer\UAS} using Scer\GAL4^nub-AC-62 results in abnormally small wings in which cell number is decreased.

(Resnik-Docampo and de Celis, 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

RagC-D^Q99L.UAS, Scer\GAL4^nub-AC-62 has abnormal size phenotype, enhanceable by hppy^UAS.cMa, Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

RagC-D^Q99L.UAS, Scer\GAL4^nub-AC-62 has decreased cell number phenotype, enhanceable by hppy^UAS.cMa, Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

Enhancer of

Statement

Reference

RagC-D^Q99L.UAS, Scer\GAL4^nub-AC-62 is an enhancer of abnormal size phenotype of Scer\GAL4^nub-AC-62, hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

RagC-D^Q99L.UAS, Scer\GAL4^nub-AC-62 is an enhancer of decreased cell size phenotype of Scer\GAL4^nub-AC-62, hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

NOT Enhancer of

Statement

Reference

RagC-D^Q99L.UAS/Scer\GAL4^pHCl-2.PR is a non-enhancer of abnormal developmental rate | recessive phenotype of pHCl-2^pTV-Cherry

(Redhai et al., 2020)

NOT Suppressor of

Statement

Reference

RagC-D^Q99L.UAS/Scer\GAL4^pHCl-2.PR is a non-suppressor of abnormal developmental rate | recessive phenotype of pHCl-2^pTV-Cherry

(Redhai et al., 2020)

Phenotype Manifest In

Enhanced by

Statement

Reference

RagC-D^Q99L.UAS, Scer\GAL4^nub-AC-62 has wing phenotype, enhanceable by hppy^UAS.cMa, Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

Enhancer of

Statement

Reference

RagC-D^Q99L.UAS, Scer\GAL4^nub-AC-62 is an enhancer of wing phenotype of Scer\GAL4^nub-AC-62, hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of hppy^Scer\UAS.cMa enhances the small wing and decreased wing cell number phenotypes seen in RagC^{Q99L.Scer\UAS}, Scer\GAL4^nub-AC-62 wings.

(Resnik-Docampo and de Celis, 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

RagC-D^{Q99L.Scer\UAS}

RagC-D^Q99L.UAS

RagC^{Q99L.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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