FlyBase Allele Report: Dmel\Actn[KK102286]

General Information

Symbol

Dmel\Actn^KK102286

Species

D. melanogaster

Name

FlyBase ID

FBal0259146

Feature type

allele

Associated gene

Dmel\Actn

Associated Insertion(s)

Carried in Construct

P{KK102286}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102286}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102286

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of focal segmental glomerulosclerosis 1

CEC

(Odenthal et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of focal segmental glomerulosclerosis 1

is ameliorated by Hsap\ACTN4^{UAS.WT.Tag:HA}

(Odenthal et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless, with Scer\GAL4¹¹⁵¹

(Czajkowski et al., 2021)

Phenotype Manifest In

indirect flight muscle cell, with Scer\GAL4^Act88F.PB

(González-Morales et al., 2019)

nephrocyte diaphragm | larval stage, with Scer\GAL4^sns.PK

(Odenthal et al., 2023)

sarcomere | adult stage, with Scer\GAL4^Act88F.PB

(González-Morales et al., 2019)

Z disc | adult stage, with Scer\GAL4^Act88F.PB

(González-Morales et al., 2019)

Detailed Description

Statement

Reference

Expressing Actn^KK102286 under the control of Scer\GAL4^Act88F.PB results in indirect flight muscles with severely perturbed sarcomere structure, and Z-discs are rarely visible.

(González-Morales et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Actn^KK102286, Scer\GAL4^sns.PK has nephrocyte diaphragm | larval stage phenotype, non-enhanceable by Hsap\ACTN4^{K255E.UAS.Tag:HA}, Scer\GAL4^sns.PK

(Odenthal et al., 2023)

Actn^KK102286, Scer\GAL4^sns.PK has nephrocyte diaphragm | larval stage phenotype, non-enhanceable by Hsap\ACTN4^{W59R.UAS.Tag:HA}, Scer\GAL4^sns.PK

(Odenthal et al., 2023)

Actn^KK102286, Scer\GAL4^sns.PK has nephrocyte diaphragm | larval stage phenotype, non-enhanceable by Hsap\ACTN4^{M240T.UAS.Tag:HA}, Scer\GAL4^sns.PK

(Odenthal et al., 2023)

Suppressed by

Statement

Reference

Actn^KK102286, Scer\GAL4^sns.PK has nephrocyte diaphragm | larval stage phenotype, suppressible | partially by Hsap\ACTN4^{UAS.WT.Tag:HA}, Scer\GAL4^sns.PK

(Odenthal et al., 2023)

NOT suppressed by

Statement

Reference

Actn^KK102286, Scer\GAL4^sns.PK has nephrocyte diaphragm | larval stage phenotype, non-suppressible by Hsap\ACTN4^{K255E.UAS.Tag:HA}, Scer\GAL4^sns.PK

(Odenthal et al., 2023)

Actn^KK102286, Scer\GAL4^sns.PK has nephrocyte diaphragm | larval stage phenotype, non-suppressible by Hsap\ACTN4^{W59R.UAS.Tag:HA}, Scer\GAL4^sns.PK

(Odenthal et al., 2023)

Actn^KK102286, Scer\GAL4^sns.PK has nephrocyte diaphragm | larval stage phenotype, non-suppressible by Hsap\ACTN4^{M240T.UAS.Tag:HA}, Scer\GAL4^sns.PK

(Odenthal et al., 2023)

Suppressor of

Statement

Reference

Actn^KK102286, Scer\GAL4^Act88F.PB is a suppressor | partially of indirect flight muscle cell phenotype of Scer\GAL4^Act88F.PB, Zasp52^UAS.PR.GFP

(González-Morales et al., 2019)

Actn^KK102286, Scer\GAL4^Act88F.PB is a suppressor | partially of sarcomere | adult stage phenotype of Scer\GAL4^Act88F.PB, Zasp52^UAS.PR.GFP

(González-Morales et al., 2019)

Actn^KK102286, Scer\GAL4^Act88F.PB is a suppressor | partially of Z disc | adult stage phenotype of Scer\GAL4^Act88F.PB, Zasp52^UAS.PR.GFP

(González-Morales et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110719

P{KK102286}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Actn^KK102286

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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