FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mdyEY07280
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General Information
Symbol
Dmel\mdyEY07280
Species
D. melanogaster
Name
FlyBase ID
FBal0260644
Feature type
allele
Associated gene
Dmel\mdy
Associated Insertion(s)
P{EPgy2}CG13280EY07280
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EPgy2}CG13280EY07280
    Cytology
    Description

    P{EPgy2}CG13280EY07280 contains Scer\UAS sites which drive expression of mdy.

    (Tian et al., 2011)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EPgy2}
    Regulatory region(s)
    UASp
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  congenital generalized lipodystrophy
        modeled by Seipinnull
        (Tian et al., 2011)
        ameliorates  congenital generalized lipodystrophy
        modeled by Seipinnull
        (Tian et al., 2011)
        Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
         

        Overexpression of mdy (using mdyEY07280) restores fat body lipid storage levels to near wild-type in Seipinnull larvae (a suppression of the lipodystrophy model in adipose tissue). However, overexpression of mdy (using mdyEY07280) increases the ectopic lipid storage phenotype observed in non-adipose tissue in Seipinnull larvae (an exacerbation of the lipodystrophy model in non-adipose tissue).

        (Tian et al., 2011)
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Expression of mdyEY07280 using either Scer\GAL4ppl.PP or Scer\GAL448Y results in ectopic lipid droplets in the salivary gland.

        (Tian et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        mdyEY07280/Scer\GAL448Y is an enhancer of salivary gland phenotype of Seipinnull

        (Tian et al., 2011)

        mdyEY07280/Scer\GAL448Y is an enhancer of lipid droplet | ectopic phenotype of Seipinnull

        (Tian et al., 2011)
        Suppressor of
        Statement
        Reference

        mdyEY07280/Scer\GAL4ppl.PP is a suppressor of fat body phenotype of Seipinnull

        (Tian et al., 2011)

        mdyEY07280/Scer\GAL4ppl.PP is a suppressor of lipid droplet phenotype of Seipinnull

        (Tian et al., 2011)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of mdyEY07280 using Scer\GAL4ppl.PP suppresses the reduced lipid storage phenotype seen in Seipinnull fat bodies.

        Overexpression of mdyEY07280 using Scer\GAL448Y in a Seipinnull mutant background results in a massive ectopic lipid storage phenotype in salivary glands.

        (Tian et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        mdyEY07280
        (Martínez et al., 2020)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)