FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Khc76
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General Information
Symbol
Dmel\Khc76
Species
D. melanogaster
Name
FlyBase ID
FBal0260819
Feature type
allele
Associated gene
Dmel\Khc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Moua et al., 2011)
Mutagen
ethyl methanesulfonate
(Djagaeva et al., 2012, Moua et al., 2011)
Progenitor genotype
Cytology
Description

Amino acid replacement: E920K.

(Djagaeva et al., 2012, Moua et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:16,267,434..16,267,434 [-]
Nucleotide change:

G16267434A

Reported nucleotide change:

C12154939T

Amino acid change:

E920K | Khc-PA

Reported amino acid change:

E920K

Comment:

Reported base location of mutation is relative to noncoding strand.

(Djagaeva et al., 2012, Moua et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Khc76/Khc27 larvae show reduced flux of both neurosecretory dense core vesicles and mitochondria along the axons compared to wild type.

      (Djagaeva et al., 2012)

      Results in larval posterior paralysis in combination with a null Khc allele.

      Both anterograde and retrograde flux of axonal mitochondria is inhibited in Khc76/Khc27 larvae.

      99% of eggs from females containing homozygous germline clones have normal dorsal appendages.

      The velocity of ooplasmic streaming in stage 9-10A and stage 10B oocytes is not significantly reduced in mutant females compared to wild type.

      (Moua et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Khc76
      (Djagaeva et al., 2012, Moua et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)