FB2026_02 , released June 18, 2026
Allele: Dmel\CtBPMono.UAS.Tag:FLAG
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General Information
Symbol
Dmel\CtBPMono.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0260870
Feature type
allele
Associated gene
Dmel\CtBP
Associated Insertion(s)
Carried in Construct
P{UAS-CtBP.Mono}
Key Links
Transgenic product class
missense_variant
(Bhambhani et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bhambhani et al., 2011)
Mutagen
in vitro construct
(Bhambhani et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-CtBP.Mono}
Cytology
Description

UAS regulatory sequences drive expression of a monomeric version of the short isoform (383 aa) of CtBP containing amino acid substitutions C134Y, N138R, R141A and R142A fused to two C-terminal Tag:FLAG tags.

(Bhambhani et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
CtBP
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of CtBPMono.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4dpp.blk1 never results in wing notching.

      (Bhambhani et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Suppressor of
      Phenotype Manifest In
      Enhancer of
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of CtBPMono.Scer\UAS.T:Zzzz\FLAG causes a significant enhancement of the small eye phenotype caused by Scer\GAL4GMR.PF-dependent expression of armS10.Scer\UAS.T:Hsap\MYC.

      Co-expression of CtBPMono.Scer\UAS.T:Zzzz\FLAG with pygoScer\UAS.cPa under the control of Scer\GAL4ptc-559.1 significantly suppresses the loss of wing-margin caused by pygoScer\UAS.cPa-overexpression with a dramatic reduction in the frequency of big notches.

      (Bhambhani et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CtBPMono.Scer\UAS.T:Zzzz\FLAG
      CtBPMono.UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (1)