FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pkd2+t1kb
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General Information
Symbol
Dmel\Pkd2+t1kb
Species
D. melanogaster
Name
FlyBase ID
FBal0260949
Feature type
allele
Associated gene
Dmel\Pkd2
Associated Insertion(s)
Carried in Construct
P{Pkd2t1kb}
Key Links
Transgenic product class
missense_variant
(Köttgen et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Köttgen et al., 2011)
Mutagen
in vitro construct
(Köttgen et al., 2011)
Progenitor genotype
Carried in construct
P{Pkd2t1kb}
Cytology
Description

P{Pkd2D627V.t1kb} is composed of approximately 1kb of 5' flanking region and the genomic region of Pkd2.

(Köttgen et al., 2011)

Amino acid replacement: D627V.

(Köttgen et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
Pkd2
Encoded product / tool
Pkd2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Pkd2+t1kb rescues Pkd21

      (Hofherr et al., 2016)

      Pkd2D627V.t1kb/Pkd2+t1kb rescues Pkd21

      (Köttgen et al., 2011)

      Pkd2+t1kb rescues Pkd21

      (Köttgen et al., 2011)
      Comments

      The almost complete male sterility observed in Pkd21/Pkd21 mutants is fully rescued by combination with Pkd2+t1kb.

      (Hofherr et al., 2016)

      The presence of Pkd2+t1kb rescues the sperm storage phenotype found in females mated with Pkd21 mutant males as well as the increase in beat frequency found when the sperm are released from the uterus.

      Pkd21 mutant male sterility can be rescued upon expression of both Pkd2+t1kb and Pkd2D627V.t1kb.

      (Köttgen et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pkd2+t1kb
      Name Synonyms
      Secondary FlyBase IDs
        References (2)