FlyBase Allele Report: Dmel\pic[5-1]

General Information

Symbol

Dmel\pic^5-1

Species

D. melanogaster

Name

FlyBase ID

FBal0261056

Feature type

allele

Associated gene

Dmel\pic

Associated Insertion(s)

Carried in Construct

Also Known As

DDB1^5-1

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Lin et al., 2009)

Progenitor genotype

pic^EY01408

(Lin et al., 2009)

Cytology

Description

Imprecise excision of P{EPgy2}pic^EY01408 results in the deletion of 45bp of the pic 5'UTR and the N-terminal 208 amino acids residues of pic.

(Lin et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:13,052,364..13,053,387 [+]

Comment:

Deletion endpoints inferred from description that it includes 45 bp of the pic 5'UTR and the N-terminal 208 amino acids of the pic protein.

(Lin et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape | larval stage

(Ly et al., 2019)

abnormal neuroanatomy | larval stage

(Ly et al., 2019)

decreased occurrence of cell division | larval stage

(Ly et al., 2019)

decreased occurrence of cell division | somatic clone

(Lin et al., 2009)

lethal - all die before end of second instar larval stage

(Lin et al., 2009)

some die during second instar larval stage

(Lin et al., 2009)

Phenotype Manifest In

follicle cell | second instar larval stage

(Lin et al., 2009)

larval brain | larval stage

(Ly et al., 2019)

larval neuroblast | larval stage

(Ly et al., 2019)

Detailed Description

Statement

Reference

pic^5-1 homozygotes exhibit larval brains with signs of quiescence: neuroblasts show a significant decrease in cell divisions (DNA replication/EdU staining); and frequently show a primary cellular process, whereas control neuroblasts show a typically rounded morphology.

pic^5-1 individuals on aminoacid-depleted food do not show changes in cell division (DNA replication/EdU staining) on mushroom body neuroblast lineages, as compared to controls.

(Ly et al., 2019)

Larvae homozygous for pic^5-1 survive till second instar larval stage.

Approximately 48% of pic^5-1 mutant follicle cell clones display reduced or absent BrdU incorporation. In addition, some cells (9.5%) display abnormal genomic replication.

(Lin et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

DDB1^5-1

(Lin et al., 2009)

ddb1^5-1

(Ly et al., 2019)

pic^5-1

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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