FlyBase Allele Report: Dmel\Hr3[ΔDBD.UAS]

General Information

Symbol

Dmel\Hr3^ΔDBD.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0261085

Feature type

allele

Associated gene

Dmel\Hr3

Associated Insertion(s)

Carried in Construct

P{UAS-Hr3.ΔDBD}

Key Links

Transgenic product class

inframe_deletion

(Montagne et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Montagne et al., 2010)

Mutagen

in vitro construct

(Montagne et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-Hr3.ΔDBD}

Cytology

Description

UAS regulatory sequences drive expression of Hr3 coding sequences lacking an upstream translational initiator codon, but retain an AUG codon, and so can potentially translate a protein lacking a DNA-binding domain-coding sequence.

(Montagne et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hr3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing, with Scer\GAL4^ap-md544

(Montagne et al., 2010)

Detailed Description

Statement

Reference

Expression of Hr46^RB.Scer\UAS under the control of Scer\GAL4^ap-md544 induces a bent-down wing phenotype.

(Montagne et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^ap-md544/Hr3^ΔDBD.UAS is a suppressor of wing phenotype of S6k^l-1

(Montagne et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

In combination with S6k^UAS.cMa, expression of Hr3^RB.UAS in the developing wing disc under the control of Scer\GAL4^ap-md544 induces a strong enhancement of the S6k^UAS.cMa-associated bent-down wing phenotype.

Co-induction of Hr3^{dsRNA.UAS.cMa} suppresses the bent-down wing phenotype seen upon induction of both S6k^UAS.cMa and Hr3^RB.UAS in the developing wing disc under the control of Scer\GAL4^ap-md544.

Expression of Hr3^ΔDBD.UAS under the control of Scer\GAL4^ap-md544 suppresses the bent-down wing phenotype found in a S6k^l-1 background.

(Montagne et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hr3^{ΔDBD.Scer\UAS}

Hr3^ΔDBD.UAS

Hr46^{ΔDBD.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close