FlyBase Allele Report: Dmel\dve[E181]

General Information

Symbol

Dmel\dve^E181

Species

D. melanogaster

Name

FlyBase ID

FBal0261110

Feature type

allele

Associated gene

Dmel\dve

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Nakagawa et al., 2011)

Progenitor genotype

Cytology

Description

Imprecise excision of P{GawB}dve^NP3060 completely removes the first exon of dve in an approximately 4kb deletion.

(Nakagawa et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mating behavior | female

(Minami et al., 2012)

abnormal mating behavior | female (with dve^E144)

(Minami et al., 2012)

decreased body size | recessive

(Minami et al., 2012)

increased cell death | P-stage (with dve^E144)

(Otsune et al., 2025)

partially lethal

(Minami et al., 2012)

partially lethal - majority die

(Nakagawa et al., 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous escaper adult males are smaller than normal.

The ratio of the cross-section areas of the accessory gland/ejaculatory bulb is significantly reduced in homozygous and dve^E181/dve^E144 males compared to wild type. The mutant accessory glands lack cells with the appearance of mature secondary cells and more than 25% of the main cells are mononucleate (in contrast to wild type where they are binucleate).

The average number of progeny of a cross of homozygous or dve^E181/dve^E144 males to wild-type females is reduced compared to a control cross of control males to wild-type females. The number of eggs laid per day by females mated to the mutant males is reduced and these females show high re-mating activity (comparable to those of virgin female controls) at 48 hours after the first mating.

(Minami et al., 2012)

dve^E181 adult escapers appear morphologically normal.

dve^E181 homozygotes and dve⁰¹⁷³⁸/dve^E181 trans-heterozygotes exhibit substantially impaired proventriculus function.

dve⁰¹⁷³⁸/dve^E181 trans-heterozygotes exhibit a mild reduction in copper absorption and acid secretion in the midgut.

(Nakagawa et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dve^E181/dve^E144 is rescued by dve^A.UAS/Scer\GAL4^dve.13

(Minami et al., 2012)

dve^E181/dve^E144 is rescued by Scer\GAL4^dve.13/dve^{B.UAS.Tag:FLAG}

(Minami et al., 2012)

Comments

The loss of secondary cells in the accessory glands of dve^E181/dve^E144 males is rescued by expression of either dve^A.Scer\UAS or dve^{B.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^dve.13.

(Minami et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dve^E181

(Otsune et al., 2025, Yan et al., 2017, Sugimori et al., 2016, Minami et al., 2012, Nakagawa et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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