FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ItprRNAi.UAS
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General Information
Symbol
Dmel\ItprRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0261171
Feature type
allele
Associated gene
Dmel\Itpr
Associated Insertion(s)
Carried in Construct
P{UAS-Itpr.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Usui-Aoki et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Usui-Aoki et al., 2005)
Mutagen
in vitro construct
(Usui-Aoki et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Itpr.RNAi}
Cytology
Description

A 474bp antisense fragment of Itp-r83A followed by the 474bp sense sequence of the Itp-r83A N-terminal region is cloned in an inverted repeat downstream of UASt regulatory sequences.

(Usui-Aoki et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Itpr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Itp-r83AdsRNA.Scer\UAS under the control of Scer\GAL4Gr5a.853 changes the sensitivity of flies to sugars, with expression resulting in less of a preference towards trehalose and an increase in consumption of sucrose. Fewer flies consumed trehalose and more flies consumed sucrose alone or both trehalose and sucrose.

      Flies expressing Itp-r83AdsRNA.Scer\UAS under the control of Scer\GAL4Gr5a.853 exhibit a decrease in trehalose consumption at a variety of trehalose concentrations.

      Expression of Itp-r83AdsRNA.Scer\UAS under the control of Scer\GAL4Gr5a.853 reduces the intake of 5mM sucrose, although this reduction is less than that seen for 5mM trehalose consumption.

      The number of impulses from I-type hairs in response to 500mM trehalose is fewer in Scer\GAL4Gr5a.853/Itp-r83AdsRNA.Scer\UAS flies than that in control flies.

      (Usui-Aoki et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Itp-r83AdsRNA.IR.Scer\UAS
      Itp-r83AdsRNA.IR.UAS
      ItprRNAi.IR.UAS
      ItprRNAi.UAS
      ItprdsRNA.IR.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)