FlyBase Allele Report: Dmel\Atg1[GL00047]

General Information

Symbol

Dmel\Atg1^GL00047

Species

D. melanogaster

Name

FlyBase ID

FBal0262537

Feature type

allele

Associated gene

Dmel\Atg1

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00047}

Also Known As

UAS-Atg1-IR, Atg1 RNAi, UAS-atg1 RNAi, GL00047

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00047}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00047

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates frontotemporal dementia and/or amyotrophic lateral sclerosis 2

modeled by Chchd2^S81L.UAS

(Baek et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile, with Scer\GAL4^{VP16.mat.αTub67C}

(Sopko et al., 2014)

Phenotype Manifest In

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Sopko et al., 2014)

embryonic/larval midgut, with Scer\GAL4^NP0001

(Denton et al., 2012)

major mitochondrial derivative, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Politi et al., 2014)

Detailed Description

Statement

Reference

The clearance of the paternal mitochondrial derivatives is mildly delayed in embryos derived from females expressing Atg1^GL00047 under the simultaneous control of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}.

(Politi et al., 2014)

Females heterozygous for Atg1^GL00047 and Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} crossed to Atg1^GL00047 males results in: 0% hatching; egg/embryonic phenotype: "anterior head defect, variable"; maternal effect.

(Sopko et al., 2014)

Scer\GAL4^{Myo31DF-NP0001}-mediated expression of Atg1^GL00047 results in persistent PI3K signalling in the midgut at +2h relative puparium formation, as assayed by localization of P{tGPH} or phospho-Akt1.

Scer\GAL4^{Myo31DF-NP0001}-mediated expression of Atg1^GL00047 severely delays midgut removal.

(Denton et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Atg1^GL00047, Scer\GAL4^NP0001 has embryonic/larval midgut phenotype, suppressible by Pten^UAS.cUa, Scer\GAL4^NP0001