FlyBase Allele Report: Dmel\Cdk8[GL00231]

General Information

Symbol

Dmel\Cdk8^GL00231

Species

D. melanogaster

Name

FlyBase ID

FBal0262702

Feature type

allele

Associated gene

Dmel\Cdk8

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00231}

Also Known As

GL00231

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00231}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00231

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of developmental and epileptic encephalopathy 87

CEA

(Chung et al., 2020)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cJa

(Ren et al., 2022)

model of developmental and epileptic encephalopathy 87

is ameliorated by Hsap\CDK19^UAS.Tag:HA

(Chung et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryo | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

NMJ bouton | decreased number | third instar larval stage, with Scer\GAL4^elav.PLu

(Chung et al., 2020)

Detailed Description

Statement

Reference

Females heterozygous for Cdk8^GL00231 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to Cdk8^GL00231 males results in: 0% hatching; egg/embryonic phenotype: "small eggs, all empty"; maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Cdk8^GL00231, Scer\GAL4^da.G32 has short lived phenotype, suppressible by Hsap\CDK19^UAS.Tag:HA, Scer\GAL4^da.G32

(Chung et al., 2020)

Cdk8^GL00231, Scer\GAL4^elav.PLu has increased mortality during development phenotype, suppressible by Hsap\CDK19^UAS.Tag:HA, Scer\GAL4^elav.PLu