FlyBase Allele Report: Dmel\sgg[GL00277]

General Information

Symbol

Dmel\sgg^GL00277

Species

D. melanogaster

Name

FlyBase ID

FBal0262746

Feature type

allele

Associated gene

Dmel\sgg

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00277}

Also Known As

sgg RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00277}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00277

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

DOES NOT ameliorate Alzheimer's disease

modeled by Hsap\MAPT^UAS.cWa

(Ando et al., 2016)

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^UAS.cBa

(Tziortzouda et al., 2024)

modeled by Hsap\FUS^{R521G.UAS.cBa}

(Tziortzouda et al., 2024)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cBa}

(Na et al., 2023)

ameliorates spinocerebellar ataxia 1

modeled by Hsap\ATXN1^82Q.UAS

(Na et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Phenotype Manifest In

embryo | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Detailed Description

Statement

Reference

Adults expressing sgg^GL00277 under the control of Scer\GAL4^GMR.PF present eye sizes comparable to controls.

(Ando et al., 2016)

Females heterozygous for sgg^GL00277 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to sgg^GL00277 males results in: 0% hatching; egg/embryonic phenotype: "small eggs, all empty"; maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

sgg^GL00277, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Ando et al., 2016)

sgg^GL00277, Scer\GAL4^GMR.PF is a non-suppressor of abnormal size | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Ando et al., 2016)

Other

Statement

Reference

Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF, sgg^GL00277 has visible phenotype

(Ando et al., 2016)

Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF, sgg^GL00277 has abnormal size | adult stage phenotype

(Ando et al., 2016)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

sgg^GL00277, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Ando et al., 2016)

Other

Statement

Reference

Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF, sgg^GL00277 has eye phenotype

(Ando et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Adults co-expressing Hsap\APP^{Aβ42.Scer\UAS.T:Rnor\SS-PENK} and sgg^GL00277 under the control of Scer\GAL4^GMR.PF have eye sizes comparable to controls.

The small eyes observed upon expression of Hsap\MAPT^Scer\UAS.cWa driven by Scer\GAL4^GMR.PF is enhanced by the co-expression of Hsap\APP^{Aβ42.Scer\UAS.T:Rnor\SS-PENK} alone; this enhancement is not suppressed by also co-expressing sgg[GL00277].

The small eyes observed upon expression of Hsap\MAPT^Scer\UAS.cWa driven by Scer\GAL4^GMR.PF are not suppressed by co-expression of sgg[GL00277].

(Ando et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

35364

y¹ sc^* v¹ sev²¹; P{TRiP.GL00277}attP2

NIG-Fly