FlyBase Allele Report: Dmel\Tl[GL00474]

General Information

Symbol

Dmel\Tl^GL00474

Species

D. melanogaster

Name

FlyBase ID

FBal0262939

Feature type

allele

Associated gene

Dmel\Tl

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00474}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00474}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00474

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Tl^GL00474/Scer\GAL4^bab1-Gal4 is a suppressor of abnormal cell number | oogenesis phenotype of Scer\GAL4^bab1-Gal4, piwi^KK105350

(Lin et al., 2020)

Scer\GAL4^en.PU/Tl^GL00474 is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

Scer\GAL4^en.PU/Tl^GL00474 is a suppressor of increased cell number | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

Scer\GAL4^da.PU/Tl^GL00474 is a suppressor | partially of lethal phenotype of Scer\GAL4^da.PU, mad2^GD16427

(Liu et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Tl^GL00474/Scer\GAL4^bab1-Gal4 is a suppressor of female germline stem cell phenotype of Scer\GAL4^bab1-Gal4, piwi^KK105350

(Lin et al., 2020)

Tl^GL00474/Scer\GAL4^bab1-Gal4 is a suppressor of germarium phenotype of Scer\GAL4^bab1-Gal4, piwi^KK105350

(Lin et al., 2020)

Scer\GAL4^en.PU/Tl^GL00474 is a suppressor | partially of wing disc posterior compartment | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

Scer\GAL4^en.PU/Tl^GL00474 is a suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

Scer\GAL4^en.PU/Tl^GL00474 is a suppressor of hemocyte | third instar larval stage phenotype of Scer\GAL4^en.PU, vtd^GL00522

(Liu et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of vtd^GL00522 under the control of Scer\GAL4^en.PU (together with Dicer-2, for efficient RNAi) leads to a significant increase in aneuploidy in the posterior compartment of the third instar larval wing disc, which is greatly suppressed by co-expressing Tl^GL00474.

Expression of vtd^GL00522 under the control of Scer\GAL4^en.PU (together with Dicer-2, for efficient RNAi) results in increased numbers of hemocytes on the surface of third instar larval wing discs, as compared to controls, which are suppressed by co-expressing Tl^GL00474.

Under 30[o]C temperature conditions, the expression of mad2^GD16427 under the control of Scer\GAL4^da.PU induces lethality before adulthood, which is partially suppressed by the co-expression of Tl^GL00474.

(Liu et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

35628

y¹ sc^* v¹ sev²¹; P{TRiP.GL00474}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Tl^GL00474

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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