FlyBase Allele Report: Dmel\Prosα5[HMS00095]

General Information

Symbol

Dmel\Prosα5^HMS00095

Species

D. melanogaster

Name

FlyBase ID

FBal0263100

Feature type

allele

Associated gene

Dmel\Prosα5

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00095}

Also Known As

UAS-Prosα5 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00095}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00095

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegenerative disease

CEA

(Fernández-Cruz et al., 2020)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | spermatogenesis, with Scer\GAL4^NP1624

(Li et al., 2026)

atrophy | male limited, with Scer\GAL4^NP1624

(Li et al., 2026)

female sterile, with Scer\GAL4^{VP16.mat.αTub67C}

(Zavortink et al., 2020)

increased cell death | spermatogenesis, with Scer\GAL4^NP1624

(Li et al., 2026)

increased occurrence of cell division | spermatogenesis, with Scer\GAL4^NP1624

(Li et al., 2026)

male sterile, with Scer\GAL4^NP1624

(Li et al., 2026)

Phenotype Manifest In

cyst cell of testis | decreased number, with Scer\GAL4^NP1624

(Li et al., 2026)

cyst progenitor cell | increased number, with Scer\GAL4^NP1624

(Li et al., 2026)

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

male fusome, with Scer\GAL4^NP1624

(Li et al., 2026)

male germline stem cell | decreased number, with Scer\GAL4^NP1624

(Li et al., 2026)

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

spermatocyte | decreased number, with Scer\GAL4^NP1624

(Li et al., 2026)

testis, with Scer\GAL4^NP1624

(Li et al., 2026)

Detailed Description

Statement

Reference

Expressing Prosα5^HMS00095 under the control of Scer\GAL4^Cg.PA leads to fuzzy and clustered mitochondria in the third instar larval fat body (as assessed by MitoGFP).

(Zhou et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

34786

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00095}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Prosα5^HMS00095

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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