FlyBase Allele Report: Dmel\Dcr-1[HMS00141]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Dcr-1^HMS00141

General Information

Symbol

Dmel\Dcr-1^HMS00141

Species

D. melanogaster

Name

FlyBase ID

FBal0263138

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00141}

Also Known As

UAS-dcr-1^RNAi

Key Links

Genomic Maps

Transgenic product class

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00141}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | adult stage, with Scer\GAL4^esg.PU

(Sreejith et al., 2025)

female semi-sterile, with Scer\GAL4^VP16.otu

(Yan and Perrimon, 2015)

lethal | female limited, with Scer\GAL4^dome-PG14

(Yan and Perrimon, 2015)

visible, with Scer\GAL4^nub-AC-62

(Yan and Perrimon, 2015)

Phenotype Manifest In

adult posterior midgut, with Scer\GAL4^esg.PU

(Sreejith et al., 2025)

wing, with Scer\GAL4^nub-AC-62

(Yan and Perrimon, 2015)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Dcr-1^HMS00141, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has decreased cell number | oogenesis phenotype

(Zhang et al., 2024)

Dcr-1^HMS00141, Scer\GAL4^{VP16.nanos.UTR}, bgcn^MI06696/bgcn¹ has decreased cell number | oogenesis phenotype

(Zhang et al., 2024)

Phenotype Manifest In

Other

Statement

Reference

Dcr-1^HMS00141, Scer\GAL4^{VP16.nanos.UTR}, bam^Δ86/bam^BG has female germline cell | absent phenotype

(Zhang et al., 2024)

Dcr-1^HMS00141, Scer\GAL4^{VP16.nanos.UTR}, bgcn^MI06696/bgcn¹ has female germline cell | absent phenotype

(Zhang et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

34826

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00141}attP2

HMS00141

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00141}attP2

Notes on Origin

Discoverer

Comments

Comments

Supplemental Dataset_S01.

(Yan and Perrimon, 2015)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Dcr-1^HMS00141

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections