FlyBase Allele Report: Dmel\Coa7[GD8140]

General Information

Symbol

Dmel\Coa7^GD8140

Species

D. melanogaster

Name

FlyBase ID

FBal0263605

Feature type

allele

Associated gene

Dmel\Coa7

Associated Insertion(s)

Carried in Construct

P{GD8140}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Mummery-Widmer et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Mummery-Widmer et al., 2009)

Mutagen

in vitro construct

(Mummery-Widmer et al., 2009)

Progenitor genotype

Carried in construct

P{GD8140}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Mummery-Widmer et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD8140

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autosomal recessive spinocerebellar ataxia with axonal neuropathy 3

CEA

(Higuchi et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR.PS

(Higuchi et al., 2018)

abnormal size | larval stage, with Scer\GAL4^elav.PLu

(Higuchi et al., 2018)

flightless, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

short lived, with Scer\GAL4^GMR.PS

(Higuchi et al., 2018)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible | adult stage, with Scer\GAL4^GMR.PU

(Shimada et al., 2020)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^elav.PLu

(Higuchi et al., 2018)

eye, with Scer\GAL4^GMR.PS

(Higuchi et al., 2018)

eye, with Scer\GAL4^GMR.PU

(Shimada et al., 2020)

Detailed Description

Statement

Reference

The expression of Coa7^GD8140 under the control of Scer\GAL4^GMR.PU induces a rough eye phenotype.

(Shimada et al., 2020)

The expression of Coa7^GD8140 under the control of Scer\GAL4^GMR.PS results in a significant decrease in lifespan, a significant decrease in locomotor capacity (in climbing assays) and a rough eye phenotype, as compared to controls. Expression under the control of Scer\GAL4^elav.PLu leads to a significant decrease in the total branch length of the larval neuromuscular junction, as compared to controls.

(Higuchi et al., 2018)

Expression under the control of Scer\GAL4^Mef2.PR results in grossly normal adult indirect flight muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in morphologically wild-type myofibrils in the adult indirect flight muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in wild-type sarcomeres in the adult indirect flight muscles.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development