FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rich2
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General Information
Symbol
Dmel\Rich2
Species
D. melanogaster
Name
FlyBase ID
FBal0263636
Feature type
allele
Associated gene
Dmel\Rich
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tong et al., 2011)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?1196term.

(Tong et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rich2 eye clones made using the 'eyFLP' system display abnormally small "on" and "off" transients in electroretinograms. However, the amplitude of depolarizations in the mutant is fairly normal. Mutant epithelial glial cells are thinner than in wild type, and the cartridges contain a highly variable number of photoreceptor cell terminals ranging from 3 to 8. However, in these missorted cartridges, active zone integrity, vesicle density and capitate projections are normal.

      chp staining of the medulla of Rich2 eye clones (made using the 'eyFLP' system) reveals a few 'gaps' as if some R7 terminals are missing.

      (Tong et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Rich2 has abnormal neuroanatomy | somatic clone phenotype, enhanceable by Rab6[+]/Rab6D23D

      (Tong et al., 2011)

      Rich2 has abnormal neuroanatomy | somatic clone phenotype, enhanceable by CadN[+]/CadN405

      (Tong et al., 2011)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Rich2 has photoreceptor cell R7 | somatic clone phenotype, enhanceable by Rab6[+]/Rab6D23D

      (Tong et al., 2011)

      Rich2 has photoreceptor cell R7 | somatic clone phenotype, enhanceable by CadN[+]/CadN405

      (Tong et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Rab6D23D/+ enhances the R7 targeting phenotype seen in Rich2 eye clones made using the 'eyFLP' system.

      CadN405/+ enhances the R7 targeting phenotype seen in Rich2 eye clones made using the 'eyFLP' system.

      (Tong et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Rich2 is rescued by Rich+t7.5

      (Tong et al., 2011)
      Comments

      Rich+t7.5 rescues the homozygous lethality and the targeting phenotypes seen in Rich2 eye clones.

      (Tong et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Molecular and phenotypic data suggest that Rich2 is a weaker allele than Rich1.

      (Tong et al., 2011)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      3L62
      (Tong et al., 2011)
      Rich2
      rich2
      (Tong et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)