FB2026_02 , released June 18, 2026
Allele: Hsap\PRDX2UAS.cWa
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General Information
Symbol
Hsap\PRDX2UAS.cWa
Species
H. sapiens
Name
FlyBase ID
FBal0263696
Feature type
allele
Associated gene
Hsap\PRDX2
Associated Insertion(s)
Carried in Construct
P{UAS-hTSA.W}
Key Links
Transgenic product class
wild_type
(Wangler et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wangler et al., 2011)
Mutagen
in vitro construct
(Wangler et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-hTSA.W}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\PRDX2 coding sequences.

(Wangler et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\PRDX2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\PRDX2Scer\UAS.cWa in the dorsal region of the wing pouch, with weaker expression ventrally, under the control of Scer\GAL4Bx-MS1096 does not lead to any abnormal phenotypes in wing development.

      Expression of Hsap\PRDX2Scer\UAS.cWa under the control of Scer\GAL471B does not alter the wild-type pattern of double row bristles or campaniform sensilla along the L3 wing vein.

      (Wangler et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of both Hsap\PRDX1Scer\UAS.cWa and Hsap\PRDX2Scer\UAS.cWa in the dorsal region of the wing pouch, with weaker expression ventrally, under the control of Scer\GAL4Bx-MS1096 does not lead to any abnormal phenotypes in wing development.

      Expression of both Hsap\PRDX1Scer\UAS.cWa and Hsap\PRDX2Scer\UAS.cWa under the control of Scer\GAL4A9 results in no obvious phenotype.

      Co-expression of either Hsap\PRDX1Scer\UAS.cWa, Hsap\PRDX2Scer\UAS.cWa or both, in the developing wing under the control of Scer\GAL4Bx-MS1096, increases the severity of the vein thickening phenotypes seen upon expression of PsnScer\UAS.cYa. The wings are also reduced in size and exhibit stronger dorsal curling.

      Co-expression of either Hsap\PRDX1Scer\UAS.cWa, Hsap\PRDX2Scer\UAS.cWa or both with PsnScer\UAS.cYa, under the control of Scer\GAL471B greatly increases the severity of ectopic clusters of both double-row bristles and campaniform sensilla and markedly enhances the number of thick ectopic sternopleural bristles.

      Co-expression of both Hsap\PRDX1Scer\UAS.cWa, Hsap\PRDX2Scer\UAS.cWa with PsnScer\UAS.cYa, under the control of Scer\GAL4A9 increases the number of ectopic bristles anterior to the eye, compared to expression of PsnScer\UAS.cYa alone.

      Co-expression of both Hsap\PRDX1Scer\UAS.cWa, Hsap\PRDX2Scer\UAS.cWa enhances the ectopic scutellar macrochaetae phenotype found upon expression of PsnScer\UAS.cYa under the control of Scer\GAL4Bx-MS1096.

      Co-expression of PsnScer\UAS.cYa, Hsap\PRDX1Scer\UAS.cWa, and Hsap\PRDX2Scer\UAS.cWa with Scer\GAL4Bx-MS1096 in flies carrying NAx-M1 only results in residual thickening of the L3 and L5 wing veins, which is significantly less severe than that observed in response to expression of PsnScer\UAS.cYa, Hsap\PRDX1Scer\UAS.cWa, and Hsap\PRDX2Scer\UAS.cWa in a wild-type background.

      The ectopic scutellar macrochaetae of flies co-expressing PsnScer\UAS.cYa, Hsap\PRDX1Scer\UAS.cWa, and Hsap\PRDX2Scer\UAS.cWa under the control of Scer\GAL4Bx-MS1096 is nearly completely suppressed by NAx-M1.

      (Wangler et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\PRDX2Scer\UAS.cWa
      Hsap\PRDX2UAS.cWa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)