FlyBase Allele Report: Dmel\Keap1[UAS.cSa]

General Information

Symbol

Dmel\Keap1^UAS.cSa

Species

D. melanogaster

Name

FlyBase ID

FBal0263738

Feature type

allele

Associated gene

Dmel\Keap1

Associated Insertion(s)

Carried in Construct

P{UAS-Keap1.S}

Also Known As

UAS-Keap1

Key Links

Transgenic product class

wild_type

(Sykiotis and Bohmann, 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Sykiotis and Bohmann, 2008)

Mutagen

in vitro construct

(Sykiotis and Bohmann, 2008)

Progenitor genotype

Carried in construct

P{UAS-Keap1.S}

Cytology

Description

UASt regulatory sequences drive expression of Keap1.

(Sykiotis and Bohmann, 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Keap1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

larval multidendritic class IV neuron | larval stage, with Scer\GAL4^ppk.PU

(Chew et al., 2021)

Detailed Description

Statement

Reference

Overexpression of Keap1^Scer\UAS.cSa in the eye under the control of Scer\GAL4^sev.EP does not distort the wild-type pattern of the ommatidia.

(Sykiotis and Bohmann, 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Keap1^UAS.cSa, Scer\GAL4^unspecified is a suppressor of increased cell growth rate | somatic clone | third instar larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^unspecified

(Nagy et al., 2013)

Keap1^UAS.cSa, Scer\GAL4^ptc-559.1 is a suppressor of abnormal size phenotype of Myc^UAS.cZa, Scer\GAL4^ptc-559.1

(Nagy et al., 2013)

Keap1^UAS.cSa, Scer\GAL4^sev.EP is a suppressor of visible phenotype of Scer\GAL4^sev.EP, cnc^UAS.cSa

(Sykiotis and Bohmann, 2008)

Phenotype Manifest In

Suppressor of

Statement

Reference

Keap1^UAS.cSa, Scer\GAL4^unspecified is a suppressor of embryonic/larval fat body | somatic clone | third instar larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^unspecified

(Nagy et al., 2013)

Keap1^UAS.cSa, Scer\GAL4^ptc-559.1 is a suppressor of first posterior wing cell phenotype of Myc^UAS.cZa, Scer\GAL4^ptc-559.1

(Nagy et al., 2013)

Keap1^UAS.cSa, Scer\GAL4^ptc-559.1 is a suppressor of first basal wing cell phenotype of Myc^UAS.cZa, Scer\GAL4^ptc-559.1

(Nagy et al., 2013)

Keap1^UAS.cSa, Scer\GAL4^sev.EP is a suppressor of ommatidium phenotype of Scer\GAL4^sev.EP, cnc^UAS.cSa

(Sykiotis and Bohmann, 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Keap1^Scer\UAS.cSa under the control of Scer\GAL4^sev.EP completely suppresses the cnc^Scer\UAS.cSa gain-of-function phenotype, restoring the eye to a wild-type morphology.

Co-expression of Keap1^Scer\UAS.cSa under the control of Scer\GAL4^GMR.PF does not modify the cnc^Scer\UAS.cVa gain-of-function phenotype in the eye.

(Sykiotis and Bohmann, 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Keap1^Scer\UAS.cSa

Keap1^UAS.cSa

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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