FB2026_03 , released September 17, 2026
Allele: Dmel\pblΔN-term-V531D.UAS.Tag:HA
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General Information
Symbol
Dmel\pblΔN-term-V531D.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0263878
Feature type
allele
Associated gene
Dmel\pbl
Associated Insertion(s)
Carried in Construct
P{UAS-pbl.ΔN-term-V531D.HA}
Key Links
Transgenic product class
inframe_deletion
(van Impel et al., 2009)
missense_variant
(van Impel et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(van Impel et al., 2009)
missense_variant
(van Impel et al., 2009)
Mutagen
in vitro construct
(van Impel et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-pbl.ΔN-term-V531D.HA}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of pbl-RA cDNA (amino acids 386-853) that lacks the N-terminal regulatory domain, with a single amino replacement (V531D) in the DH domain (this mutation has been shown to compromise catalytic activity). The coding sequence is tagged at the C-terminal end with Tag:HA.

(van Impel et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
pbl
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4e22c-mediated expression of pblΔN-term-V531D.Scer\UAS.T:Ivir\HA1 results in 0.9% embryonic lethality with 0% of embryos showing some loss of naked cuticle on the ventral side.

      (Greer et al., 2013)

      Expression of pblΔN-term-V531D.Scer\UAS.T:Ivir\HA1 in the mesoderm under the control of the Scer\GAL4twi.2PE and Scer\GAL4Mef2.PR drivers does not produce any mesodermal invagination or migration defects.

      (van Impel et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pblΔN-term-V531D.Scer\UAS.T:Ivir\HA1
      pblΔN-term-V531D.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)