FlyBase Allele Report: Dmel\esn[KO6]

General Information

Symbol

Dmel\esn^KO6

Species

D. melanogaster

Name

FlyBase ID

FBal0264013

Feature type

allele

Associated gene

Dmel\esn

Associated Insertion(s)

TI{TI}esn^KO6

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Matsubara et al., 2011)

Mutagen

ends-out gene targeting

(Matsubara et al., 2011)

FLPase

(Matsubara et al., 2011)

I-SceI

(Matsubara et al., 2011)

Progenitor genotype

Associated Insertion(s)

TI{TI}esn^KO6

Cytology

Description

The esn coding region has been replaced by a w[+] marker.

(Matsubara et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | male (with esn^f00447)

(Jin et al., 2020)

abnormal neuroanatomy | third instar larval stage

(Matsubara et al., 2011)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4⁴⁷⁷, esn^GD7841

(Matsubara et al., 2011)

fertile

(Matsubara et al., 2011)

viable

(Matsubara et al., 2011)

Phenotype Manifest In

dendrite | third instar larval stage

(Matsubara et al., 2011)

dendrite | third instar larval stage, with Scer\GAL4⁴⁷⁷, esn^GD7841

(Matsubara et al., 2011)

larval dorsal multidendritic neuron ddaC | third instar larval stage

(Matsubara et al., 2011)

larval dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4⁴⁷⁷, esn^GD7841

(Matsubara et al., 2011)

Detailed Description

Statement

Reference

Homozygotes display no obvious defects in planar cell polarity in the wing or notum or in the morphology of the compound eye.

The dendrites of the dendritic arbor of the ddaC class IV neurons show an increase in crossing index in homozygous third instar larvae compared to wild type, although the cumulative branch length of the dendrites is unchanged in the mutant larvae.

The dendrites of the dendritic arbor of the ddaC class IV neurons show an increase in crossing index in esn^KO6/+ larvae expressing esn^GD7841 under the control of Scer\GAL4⁴⁷⁷, although the cumulative branch length of the dendrites is unchanged in the mutant larvae.

(Matsubara et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

esn^KO6, stan[+]/stan^E59 has abnormal neuroanatomy | third instar larval stage phenotype

(Matsubara et al., 2011)

Phenotype Manifest In

Other

Statement

Reference

esn^KO6, stan[+]/stan^E59 has dendrite | third instar larval stage phenotype

(Matsubara et al., 2011)

esn^KO6, stan[+]/stan^E59 has larval dorsal multidendritic neuron ddaC | third instar larval stage phenotype

(Matsubara et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

stan^E59/esn^KO6 double heterozygous larvae show increased crossing of dendrites in the dendritic arbor of the ddaC class IV neurons compared to wild type (neither single heterozygote shows this phenotype).

(Matsubara et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

esn^KO6 is rescued by Scer\GAL4⁴⁷⁷/esn^{UAS.FL.Tag:FLAG}

(Matsubara et al., 2011)

Not rescued by

esn^KO6 is not rescued by esn^{ΔLIM.UAS.Tag:FLAG}/Scer\GAL4⁴⁷⁷

(Matsubara et al., 2011)

Comments

Expression of esn^{Scer\UAS.FL.T:Zzzz\FLAG} under the control of Scer\GAL4⁴⁷⁷ rescues the increased crossing that is seen in the dendritic arbor of the ddaC class IV neurons in homozygous esn^KO6 third instar larvae.

Expression of esn^{ΔLIM.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4⁴⁷⁷ does not rescue the increased crossing that is seen in the dendritic arbor of the ddaC class IV neurons in homozygous esn^KO6 third instar larvae.

(Matsubara et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

esn^KO6

(Arguello et al., 2021, Jin et al., 2020, Matsubara et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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