FB2026_02 , released June 18, 2026
Allele: Dmel\par-629VV
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General Information
Symbol
Dmel\par-629VV
Species
D. melanogaster
Name
FlyBase ID
FBal0264146
Feature type
allele
Associated gene
Dmel\par-6
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Jones and Metzstein, 2011)
Mutagen
ethyl methanesulfonate
(Jones and Metzstein, 2011)
Progenitor genotype
Cytology
Description

Amino acid replacement: M1I.

(Jones and Metzstein, 2011)

Nucleotide substitution: G3A.

(Jones and Metzstein, 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:17,703,653..17,703,653 [+]
Nucleotide change:

G17703653A

Reported nucleotide change:

G3A

Amino acid change:

M1I | par-6-PA; M1I | par-6-PB

Reported amino acid change:

M1I

(Jones and Metzstein, 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous tracheal terminal cells show normal class I branching, but subsequent branching is much reduced compared to wild type, so that the mutant cells have many fewer higher order branches than normal. In addition, the mutant cells lack gas-filled lumens, apart from in a region at the proximal end of the cell near the nucleus. In contrast to the tapered branch tips seen in wild type, the tips of mutant branches often appear bulbous (in some cases this appear to be due to a simple accumulation of cytoplasm, while in other cases, the abnormal tips appear to contain internal membraneous structures).

      Hemizygous embryos have a large hole in the cuticle. par-629VV/par-615N embryos have occasional small holes in the cuticle.

      (Jones and Metzstein, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increase in branching seen in tracheal terminal cells expressing btlScer\UAS.T:λ\cI-DD under the control of Scer\GAL4btl.PS is suppressed in a par-629VV mutant background, but the double mutant cells still show increased cell growth.

      (Jones and Metzstein, 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      par-629VV is rescued by par-6+tPa

      (Jones and Metzstein, 2011)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      par-629VV
      (Jones and Metzstein, 2011)
      par-629vv
      (Wu et al., 2023)
      par629VV
      (Nunes de Almeida et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)