FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\spasUAS.CFP
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General Information
Symbol
Dmel\spasUAS.CFP
Species
D. melanogaster
Name
FlyBase ID
FBal0264222
Feature type
allele
Associated gene
Dmel\spas
Associated Insertion(s)
Carried in Construct
P{UAS-spas.CFP}
Also Known As
UAS-CFP-Dspastin
Key Links
Transgenic product class
genomic_DNA
(Du et al., 2010)
wild_type
(Du et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Du et al., 2010)
wild_type
(Du et al., 2010)
Mutagen
in vitro construct
(Du et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-spas.CFP}
Cytology
Description

UASt regulatory sequences drive expression of a genomic fragment that spans from the first ATG to the 3'UTR of spas, tagged at the 5' end with CFP.

(Du et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
spas
Tagged with
CFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of spasScer\UAS.T:Avic\GFP-CFP in larval muscles under the control of Scer\GAL4how-24B results in disruption to the microtubule network.

      (Du et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4elav.Switch.PO/spasUAS.CFP partially rescues spas5.75

      (Du et al., 2010)
      Comments

      Expression of spasScer\UAS.T:Avic\GFP-CFP under the control of Scer\GAL4elav.Switch.PO partially rescues the eclosion defects seen in spas5.75 homozygotes. Increasing spas expression levels through increasing the number of transgenes or the concentration of RU486 does not further improve eclosion rates.

      Expression of spasScer\UAS.T:Avic\GFP-CFP under the control of Scer\GAL4elav.Switch.PO fully rescues the behavioural defects seen in spas5.75 homozygotes. Rescued flies are able to fly, jump and crawl comparably to wild type flies.

      (Du et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      spasScer\UAS.T:Avic\GFP-CFP
      spasUAS.CFP
      Name Synonyms
      Secondary FlyBase IDs
        References (3)