FlyBase Allele Report: Dmel\Sirt1[UASp.Tag:MYC]

General Information

Symbol

Dmel\Sirt1^UASp.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0264278

Feature type

allele

Associated gene

Dmel\Sirt1

Associated Insertion(s)

Carried in Construct

P{UASp-Sirt1.Myc}

Also Known As

UAS-Sir2-myc, UAS-sir2, UAS-SIRT1

Key Links

Transgenic product class

wild_type

(Burnett et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Burnett et al., 2011)

Mutagen

in vitro construct

(Burnett et al., 2011)

Progenitor genotype

Carried in construct

P{UASp-Sirt1.Myc}

Cytology

Description

UASp regulatory sequences drive expression of Sirt1 which is tagged with Tag:MYC.

(Burnett et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Sirt1

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Barth syndrome

modeled by Taz⁸⁸⁹

(Damschroder et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased sleep | adult stage, with Scer\GAL4^repo.PU

(Cho et al., 2026)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Sirt1^{Scer\UAS.P\T.T:Hsap\MYC} under the control of Scer\GAL4^tin.CΔ4 does not affect the survival of adults under paraquat-induced oxidative stress.

(Kopp et al., 2015)

Flies expressing Sir2^{Scer\UAS.P\T.T:Hsap\MYC} under the control of Scer\GAL4^tub.PU show no increase in lifespan compared to the control carrying the Scer\GAL4^tub.PU driver alone.

(Burnett et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^repo.PU, Sirt1^UASp.Tag:MYC has decreased sleep | adult stage phenotype, suppressible | partially by eater¹

(Cho et al., 2026)

NOT Enhancer of