FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Apc2UAS.Tag:Myr(Src64B),Tag:FLAG
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General Information
Symbol
Dmel\Apc2UAS.Tag:Myr(Src64B),Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0264334
Feature type
allele
Associated gene
Dmel\Apc2
Associated Insertion(s)
Carried in Construct
P{UAS-Apc2.myr}
Key Links
Transgenic product class
wild_type
(Tolwinski, 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tolwinski, 2009)
Mutagen
in vitro construct
(Tolwinski, 2009)
Progenitor genotype
Carried in construct
P{UAS-Apc2.myr}
Cytology
Description

UAS regulatory sequences drive expression of Apc2 with Tag:Myr(Src64B) added to its N-terminus for myristoylation and membrane targeting, and Tag:FLAG fused to its C-terminus.

(Tolwinski, 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Apc2
Tagged with
Tag:FLAG
Tag:Myr(Src64B)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos expressing Apc2Scer\UAS.T:Src64B,T:Zzzz\FLAG under the control of Scer\GAL4da.G32 show mainly normal patterning, although occasional extra denticles can be observed.

      (Tolwinski, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Apc2Scer\UAS.T:Src64B,T:Zzzz\FLAG under the control of Scer\GAL4da.G32 has no effect on the ventral denticle belt phenotype of the germ-line and zygotic AxnS044230-mutants.

      Expression of Apc2Scer\UAS.T:Src64B,T:Zzzz\FLAG under the control of Scer\GAL4da.G32 fails to restore wild-type patterning of the ventral cuticle in ApcQ8, Apc2d40 double mutant embryos.

      Expression of Apc2Scer\UAS.T:Src64B,T:Zzzz\FLAG under the control of Scer\GAL4da.G32 has no effect on the ventral denticle belt phenotype of AxnS044230, ApcQ8, Apc2d40 triple mutants.

      Expression of Apc2Scer\UAS.T:Src64B,T:Zzzz\FLAG has no effect on the ventral denticle belt phenotype of sggM11 mutant embryos.

      (Tolwinski, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Apc2Scer\UAS.T:Myr-Src64B,T:Zzzz\FLAG
      Apc2Scer\UAS.T:Src64B,T:Zzzz\FLAG
      Apc2UAS.Tag:Myr(Src64B),Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)