FlyBase Allele Report: Dmel\E2f1[RNAi.C.UAS]

General Information

Symbol

Dmel\E2f1^RNAi.C.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0264338

Feature type

allele

Associated gene

Dmel\E2f1

Associated Insertion(s)

Carried in Construct

P{UAS-E2f1.C.RNAi}

Key Links

Transgenic product class

RNAi_reagent

(Li and Lu, 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Li and Lu, 2009)

Mutagen

in vitro construct

(Li and Lu, 2009)

Progenitor genotype

Carried in construct

P{UAS-E2f1.C.RNAi}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi construct targeting E2f-RC.

(Li and Lu, 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

E2f1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Li and Lu, 2009)

visible, with Scer\GAL4^I-76-D

(Li and Lu, 2009)

Phenotype Manifest In

antenna

(Li and Lu, 2009)

antenna, with Scer\GAL4^I-76-D

(Li and Lu, 2009)

eye

(Li and Lu, 2009)

eye, with Scer\GAL4^I-76-D

(Li and Lu, 2009)

Detailed Description

Statement

Reference

Approximately 1% of flies expressing E2f^{dsRNA.C.Scer\UAS} under the control of Scer\GAL4^I-76-D display eye defects and antenna duplication (always on the same side of as the deformed eye).

A fraction of animals harboring E2f^{dsRNA.C.Scer\UAS} display eye defects without any Scer\GAL4 driver.

(Li and Lu, 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

E2f1^RNAi.C.UAS, Scer\GAL4^I-76-D has visible phenotype, suppressible by piwi¹

(Li and Lu, 2009)

E2f1^RNAi.C.UAS, Scer\GAL4^I-76-D has visible phenotype, suppressible by AGO1⁰⁴⁸⁴⁵

(Li and Lu, 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

E2f1^RNAi.C.UAS, Scer\GAL4^I-76-D has eye phenotype, suppressible by piwi¹

(Li and Lu, 2009)

E2f1^RNAi.C.UAS, Scer\GAL4^I-76-D has antenna phenotype, suppressible by piwi¹

(Li and Lu, 2009)

E2f1^RNAi.C.UAS, Scer\GAL4^I-76-D has eye phenotype, suppressible by AGO1⁰⁴⁸⁴⁵

(Li and Lu, 2009)

E2f1^RNAi.C.UAS, Scer\GAL4^I-76-D has antenna phenotype, suppressible by AGO1⁰⁴⁸⁴⁵

(Li and Lu, 2009)

Additional Comments

Genetic Interactions

Statement

Reference

piwi¹ suppresses the eye and antenna traits of flies expressing E2f^{dsRNA.C.Scer\UAS} under the control of Scer\GAL4^I-76-D.

AGO1⁰⁴⁸⁴⁵ suppresses the eye and antenna traits of flies expressing E2f^{dsRNA.C.Scer\UAS} under the control of Scer\GAL4^I-76-D.

(Li and Lu, 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

E2f1^RNAi.C.UAS

E2f1^{dsRNA.C.Scer\UAS}

E2f1^dsRNA.C.UAS

E2f^{dsRNA.C.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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