FB2026_02 , released June 18, 2026
Allele: Dmel\Gαq28
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General Information
Symbol
Dmel\Gαq28
Species
D. melanogaster
Name
FlyBase ID
FBal0264676
Feature type
allele
Associated gene
Dmel\Gαq
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Yao and Carlson, 2010)
Progenitor genotype
P{GawB}GαqNP6216
(Yao and Carlson, 2010)
Cytology
Description

Imprecise excision of the progenitor insertion has resulted in a 5428bp deletion that removes the first eight exons of the Gα49B 3 isoform.

(Yao and Carlson, 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:12,612,788..12,618,215 [+]
Comment:

Inferred boundaries of a 5428bp deletion resulting from the imprecise excision of P{GawB}GalphaqNP6216 that removes the first eight exons of Galphaq.

(Yao and Carlson, 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Gαq28/+ mutant larvae show a small decrease in spontaneous miniature neurotransmission. A compensatory increase in quantal content means that evoked neurotransmission is unaffected.

      (Brusich et al., 2015)

      Homozygous ab3A ORNs generated using MARCM show a normal odour response to methyl butyrate and to butyric acid.

      (Yao and Carlson, 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Other
      Statement
      Reference

      Galphaq[+]/Gαq28, GluRIIASP16 has abnormal neurophysiology phenotype

      (Brusich et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of Gαq28 prevents the compensatory increase in quantal content seen in the NMJs of GluRIIASP16 mutant larvae with reduced quantal size, resulting in impaired evoked neurotransmission. There is no increase in quantal content compared with Gαq28/+ controls.

      (Brusich et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Gq28
      (Brusich et al., 2018)
      Gα49B28
      Gαq28
      (Yao and Carlson, 2010)
      Gαq28
      (Brusich et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)