FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NakKD.UAS.Tag:MYC
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General Information
Symbol
Dmel\NakKD.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0264902
Feature type
allele
Associated gene
Dmel\Nak
Associated Insertion(s)
Carried in Construct
P{UAS-Nak.KD}
Key Links
Transgenic product class
missense_variant
(Yang et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yang et al., 2011)
Mutagen
in vitro construct
(Yang et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Nak.KD}
Cytology
Description

UAS regulatory sequences drive expression of a mutated form of Nak, which contains the amino acid replacements K79R and R304K (kinase dead mutant). The protein is also tagged with Tag:MYC.

(Yang et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Nak
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The number of dendritic endpoints of dorsal dendritic arborisation neurons is reduced compared to controls in larvae expressing NakKD.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4109(2)80.

      (Yang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4109(2)80/NakKD.UAS.Tag:MYC fails to rescue NakRNAi.UAS

      (Yang et al., 2011)

      Scer\GAL4elav-C155/NakKD.UAS.Tag:MYC fails to rescue NakRNAi.UAS

      (Yang et al., 2011)
      Comments

      Co-expression of NakKD.Scer\UAS.T:Hsap\MYC fails to rescue the dendritic defects seen in the dorsal dendritic arborisation neurons of larvae expressing NakdsRNA.Scer\UAS under the control of Scer\GAL4109(2)80.

      Co-expression of NakKD.Scer\UAS.T:Hsap\MYC fails to rescue the dendritic defects seen in the dorsal dendritic arborisation neurons of larvae expressing NakdsRNA.Scer\UAS under the control of Scer\GAL4elav-C155.

      (Yang et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      NakKD.Scer\UAS.T:Hsap\MYC
      NakKD.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)