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General Information
Symbol
Dmel\Caf1-55med
Species
D. melanogaster
Name
FlyBase ID
FBal0265621
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    G15226967A

    Amino acid change:

    W305term | Caf1-55-PA; W304term | Caf1-55-PB

    Reported amino acid change:

    W304term

    Comment:

    G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: W304term.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous larvae appear grossly normal but mature slowly and die as first or second instars.

    Approximately 20% of flies containing clones induced using the ey-FLP; FRT cell lethal system have extra or missing appendages on the head, including the ocelli, antennae and maxillary palps.

    Caf1short/Caf1med flies expressing Caf1Scer\UAS.cAa under the control of Scer\GAL4Ubi and raised at 18[o]C during the third larval instar stage have disorganised kidney-shaped eyes with abnormalities in the arrangement of rhabdomeres (including loss of small central rhabdomeres) and show homeotic transformation of the arista to leg-like structures that occasionally end in claws. These defects are not seen if the animals are raised at 25[o]C during the third larval instar stage.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressor of
    Statement
    Reference

    Caf1-55med/Caf1[+] is a suppressor of visible phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

    Phenotype Manifest In
    Suppressor of
    Statement
    Reference

    Caf1-55med/Caf1[+] is a suppressor of eye phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The mutant eye phenotype caused by expression of sensScer\UAS.cNa under the control of Scer\GAL4lz-gal4 is dominantly suppressed by Caf1med.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Partially rescued by
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Caf1-55med
    Name Synonyms
    Secondary FlyBase IDs
      References (2)