FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rae1UAS.EGFP
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General Information
Symbol
Dmel\Rae1UAS.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0265661
Feature type
allele
Associated gene
Dmel\Rae1
Associated Insertion(s)
Carried in Construct
P{UAS-Rae1.EGFP}
Also Known As
UAS-GFP-rae1
Key Links
Transgenic product class
wild_type
(Tian et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tian et al., 2011)
Mutagen
in vitro construct
(Tian et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Rae1.EGFP}
Cytology
Description

UAS regulatory sequences drive expression of Rae1 sequences tagged with EGFP.

(Tian et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Rae1
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Rae1Scer\UAS.T:Avic\GFP-EGFP completely suppresses the synaptic overgrowth phenotypes seen upon expression of hiwΔN.Scer\UAS.T:Zzzz\TAP under the control of Scer\GAL4BG380.

      (Tian et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4Tub.PU/Rae1UAS.EGFP partially rescues Rae1Z5584

      (Volpi et al., 2013)
      Comments

      Expression of Rae1Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4tub.PU fails to rescue the sterility of homozygous Rae1Z5584 males. However, there is partial rescue of the meiotic defects seen in the testes of these animals. No nuclear herniations are seen in rescued primary spermatocytes, chromosome segregation appear normal at metaphase I and onion stage spermatids have the 1:1 nucleus to Nebenkern ratio typical of wild-type (although their shape is irregular in some cases). Spermatid elongation is seen, but the cysts still show the nuclear misalignment seen in non-rescued homozygotes. Nuclear morphology of elongating spermatids is intermediate between that of wild type and the non-rescued mutants. Meiosis I and II can progress and reach completion in the testes of the rescued males, but this is variable.

      (Volpi et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rae1Scer\UAS.T:Avic\GFP-EGFP
      Rae1UAS.EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (2)