FB2026_02 , released June 18, 2026
Allele: Dmel\TBPHex26
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General Information
Symbol
Dmel\TBPHex26
Species
D. melanogaster
Name
FlyBase ID
FBal0265707
Feature type
allele
Associated gene
Dmel\TBPH
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lin et al., 2011)
Mutagen
P-element activity
(Lin et al., 2011)
Progenitor genotype
P{SUPor-P}TBPHKG08578
(Lin et al., 2011)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 932bp deletion in the 5' end of the TBPH gene.

(Lin et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Most homozygotes survive to the early pupal stage, but only approximately 10% of homozygotes eclose. Most of the flies are trapped in the pupal case and those that do eclose show severe defects in locomotion.

      Homozygous third instar larvae show severe defects in locomotion.

      The number of synaptic boutons normalised to the muscle area is increased by approximately 35% at the third larval instar neuromuscular junction.

      (Lin et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      TBPHex26 is rescued by TBPHUAS.cLa/Scer\GAL4Toll-6-D42

      (Lin et al., 2011)
      Comments

      The locomotion defects and the increased number of synaptic boutons at the neuromuscular junction which are seen in TBPHex26 larvae are fully and partially rescued respectively by expression of TBPHScer\UAS.cLa under the control of Scer\GAL4D42.

      (Lin et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TBPHex26
      dTDPex26
      (Lin et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)