FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mkk4Asp.UAS
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General Information
Symbol
Dmel\Mkk4Asp.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0265751
Feature type
allele
Associated gene
Dmel\Mkk4
Associated Insertion(s)
Carried in Construct
P{UAS-Mkk4.Asp}
Key Links
Transgenic product class
missense_variant
(Geuking et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Geuking et al., 2009)
Mutagen
in vitro construct
(Geuking et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Mkk4.Asp}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of Mkk4 in which the serine at amino acid 277 and the threonine at amino acid 281 have been replaced by an aspartic acid.

(Geuking et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mkk4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Mkk4Asp.UAS, Scer\GAL4GMR.PF is a suppressor of eye phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Geuking et al., 2009)
      NOT Suppressor of
      Statement
      Reference

      Mkk4Asp.UAS, Scer\GAL4GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4GMR.PF, hepCA.UAS

      (Geuking et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Mkk4Asp.Scer\UAS suppresses the small eye phenotype seen when egrScer\UAS.cMa is expression of Scer\GAL4GMR.PF.

      Co-expression of Mkk4Asp.Scer\UAS is unable to suppress the small eye phenotype seen when hepCA.Scer\UAS is expression of Scer\GAL4GMR.PF.

      (Geuking et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mkk4Asp.Scer\UAS
      Mkk4Asp.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)