Overexpression of LapsynScer\UAS.cGa under the control of Scer\GAL4Act.PU partially rescues the lethality of both Lapsynzg1/Df(2R)Exel6072 and homozygous Lapsynzg1 mutants. The rescued homozygous Lapsynzg1 animals emerge as adults and show no obvious behavioural abnormalities. Similar results are obtained using Scer\GAL4αTub84B.PL.
Overexpression of LapsynScer\UAS.cGa under the control of Scer\GAL4elav-C155 partially rescues the lethality of homozygous Lapsynzg1. The rescued animals survive to the pupal stage, but they fail to eclose as adults.
Overexpression of LapsynScer\UAS.cGa via Scer\GAL4Mhc.PU fails to rescue the lethality of homozygous Lapsynzg1. Homozygous Lapsynzg1 mutants expressing LapsynScer\UAS.cGa under the control of Scer\GAL4Mhc.PU die as embryos.
Presynaptic expression of LapsynScer\UAS.cGa driven by Scer\GAL4elav-C155 can rescue the satellite bouton phenotype of heterozygous Lapsynzg1. However, expression of LapsynScer\UAS.cGa under the control of Scer\GAL4elav-C155 fails to rescue the learning defects in heterozygous Lapsynzg1 larvae.