FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LapsynUAS.cGa
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General Information
Symbol
Dmel\LapsynUAS.cGa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Guan
FlyBase ID
FBal0265768
Feature type
allele
Associated gene
Dmel\Lapsyn
Associated Insertion(s)
Carried in Construct
P{UAS-Lapsyn}
Also Known As
UAS-Lapsyn
Key Links
Transgenic product class
wild_type
(Guan et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Guan et al., 2011)
Mutagen
in vitro construct
(Guan et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Lapsyn}
Cytology
Description

UAS regulatory sequences drive expression of Lapsyn.

(Guan et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Lapsyn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Presynaptic overexpression of LapsynScer\UAS.cGa under the control of Scer\GAL4elav-C155 results in a statistically significant increase in overall varicosity number, without the formation of satellite boutons.

      Postsynaptic overexpression of LapsynScer\UAS.cGa under the control of Scer\GAL4how-24B results in a statistically significant decrease in synaptic varicosity number.

      (Guan et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4Act.PU/LapsynUAS.cGa partially rescues Df(2R)Exel6072/Lapsynzg1

      (Guan et al., 2011)

      Scer\GAL4elav-C155/LapsynUAS.cGa partially rescues Lapsynzg1

      (Guan et al., 2011)

      Scer\GAL4Act.PU/LapsynUAS.cGa partially rescues Lapsynzg1

      (Guan et al., 2011)

      LapsynUAS.cGa/Scer\GAL4αTub84B.PL partially rescues Lapsynzg1

      (Guan et al., 2011)

      Scer\GAL4elav-C155/LapsynUAS.cGa partially rescues [+]/Lapsynzg1

      (Guan et al., 2011)
      Fails to rescue

      LapsynUAS.cGa/Scer\GAL4Mhc.PU fails to rescue Lapsynzg1

      (Guan et al., 2011)
      Comments

      Overexpression of LapsynScer\UAS.cGa under the control of Scer\GAL4Act.PU partially rescues the lethality of both Lapsynzg1/Df(2R)Exel6072 and homozygous Lapsynzg1 mutants. The rescued homozygous Lapsynzg1 animals emerge as adults and show no obvious behavioural abnormalities. Similar results are obtained using Scer\GAL4αTub84B.PL.

      Overexpression of LapsynScer\UAS.cGa under the control of Scer\GAL4elav-C155 partially rescues the lethality of homozygous Lapsynzg1. The rescued animals survive to the pupal stage, but they fail to eclose as adults.

      Overexpression of LapsynScer\UAS.cGa via Scer\GAL4Mhc.PU fails to rescue the lethality of homozygous Lapsynzg1. Homozygous Lapsynzg1 mutants expressing LapsynScer\UAS.cGa under the control of Scer\GAL4Mhc.PU die as embryos.

      Presynaptic expression of LapsynScer\UAS.cGa driven by Scer\GAL4elav-C155 can rescue the satellite bouton phenotype of heterozygous Lapsynzg1. However, expression of LapsynScer\UAS.cGa under the control of Scer\GAL4elav-C155 fails to rescue the learning defects in heterozygous Lapsynzg1 larvae.

      (Guan et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      LapsynScer\UAS.cGa
      LapsynUAS.cGa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Guan
      Secondary FlyBase IDs
        References (2)