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General Information
Symbol
Dmel\LapsynUAS.cGa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Guan
FlyBase ID
FBal0265768
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Lapsyn.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Presynaptic overexpression of LapsynScer\UAS.cGa under the control of Scer\GAL4elav-C155 results in a statistically significant increase in overall varicosity number, without the formation of satellite boutons.

Postsynaptic overexpression of LapsynScer\UAS.cGa under the control of Scer\GAL4how-24B results in a statistically significant decrease in synaptic varicosity number.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to rescue
Comments

Overexpression of LapsynScer\UAS.cGa under the control of Scer\GAL4Act.PU partially rescues the lethality of both Lapsynzg1/Df(2R)Exel6072 and homozygous Lapsynzg1 mutants. The rescued homozygous Lapsynzg1 animals emerge as adults and show no obvious behavioural abnormalities. Similar results are obtained using Scer\GAL4αTub84B.PL.

Overexpression of LapsynScer\UAS.cGa under the control of Scer\GAL4elav-C155 partially rescues the lethality of homozygous Lapsynzg1. The rescued animals survive to the pupal stage, but they fail to eclose as adults.

Overexpression of LapsynScer\UAS.cGa via Scer\GAL4Mhc.PU fails to rescue the lethality of homozygous Lapsynzg1. Homozygous Lapsynzg1 mutants expressing LapsynScer\UAS.cGa under the control of Scer\GAL4Mhc.PU die as embryos.

Presynaptic expression of LapsynScer\UAS.cGa driven by Scer\GAL4elav-C155 can rescue the satellite bouton phenotype of heterozygous Lapsynzg1. However, expression of LapsynScer\UAS.cGa under the control of Scer\GAL4elav-C155 fails to rescue the learning defects in heterozygous Lapsynzg1 larvae.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
LapsynScer\UAS.cGa
LapsynUAS.cGa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Guan
Secondary FlyBase IDs
    References (1)