FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cnx99A2
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General Information
Symbol
Dmel\Cnx99A2
Species
D. melanogaster
Name
FlyBase ID
FBal0265974
Feature type
allele
Associated gene
Dmel\Cnx99A
Associated Insertion(s)
Carried in Construct
Also Known As
cnx2
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Rosenbaum et al., 2006)
Mutagen
ethyl methanesulfonate
(Rosenbaum et al., 2006)
Progenitor genotype
Cytology
Description

Mutants display severely reduced levels of Cnx99A transcript and no Cnx99A protein.

(Rosenbaum et al., 2006)

Nucleotide substitution: G356A.

(Rosenbaum et al., 2006)

Amino acid replacement: W119term.

(Rosenbaum et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:29,318,401..29,318,401 [-]
Nucleotide change:

G29318401A

Reported nucleotide change:

G356A

Amino acid change:

W119term | Cnx99A-PA; W119term | Cnx99A-PB; W119term | Cnx99A-PD; W119term | Cnx99A-PE

Reported amino acid change:

W119term

Comment:

TGG to TAG nonsense mutation in codon Trp119.

(Rosenbaum et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cnx99A2 homozygotes show a significant decrease in adult locomotion capacity in negative geotaxis assays, as compared to controls.

      (Xiao et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Cnx99A2 is partially rescued by Scer\GAL4elav.PU/Cnx99AUAS.Tag:FLAG

      (Xiao et al., 2017)

      Cnx99A2 is partially rescued by Scer\GAL4elav.PU/Cnx99AC.UAS.Tag:FLAG

      (Xiao et al., 2017)
      Not rescued by

      Cnx99A2 is not rescued by Scer\GAL4elav.PU/Cnx99AN.UAS.Tag:FLAG

      (Xiao et al., 2017)
      Comments

      The adult locomotion defects observed in Cnx99A2 homozygotes are partially rescued by the expression of Cnx99AScer\UAS.T:Zzzz\FLAG, but fail to be rescued by the expression of either Cnx99AN.Scer\UAS.T:Zzzz\FLAG or Cnx99AN.Scer\UAS.T:Zzzz\FLAG (all these expressions are driven by Scer\GAL4elav.PU).

      (Xiao et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Cnx99A2
      cnx99A2
      (Rosenbaum et al., 2006)
      cnx2
      (Xiao et al., 2017, Rosenbaum et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)