FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mbcUAS.cBa
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General Information
Symbol
Dmel\mbcUAS.cBa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Balagopalan
FlyBase ID
FBal0266174
Feature type
allele
Associated gene
Dmel\mbc
Associated Insertion(s)
Carried in Construct
P{UAS-mbc.B}
Also Known As
UAS-mbc
Key Links
Transgenic product class
cDNA
(Balagopalan et al., 2006)
wild_type
(Balagopalan et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Balagopalan et al., 2006)
wild_type
(Balagopalan et al., 2006)
Mutagen
in vitro construct
(Balagopalan et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-mbc.B}
Cytology
Description

UASt drives expression of the +521 to 7035 region of a 7035 bp mbc cDNA.

(Balagopalan et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mbc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4Mef2.PR-mediated expression of mbcScer\UAS.cBa does not cause any obvious muscle perturbations.

      Scer\GAL4GMR.PU-mediated expression of mbcScer\UAS.cBa does not impact on ommatidial organization.

      (Geisbrecht et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Ced-12UAS.cGa, Scer\GAL4Mef2.PR, mbcUAS.cBa has visceral muscle fiber | embryonic stage phenotype, suppressible by Rac1J11/Rac2Δ/Rac2[+]/Rac1[+]

      (Liu et al., 2013)

      Ced-12UAS.cGa, Scer\GAL4Mef2.PR, mbcUAS.cBa has tendon cell | embryonic stage phenotype, suppressible by Rac1J11/Rac2Δ/Rac2[+]/Rac1[+]

      (Liu et al., 2013)

      Ced-12UAS.cGa, Scer\GAL4Mef2.PR, mbcUAS.cBa has eye phenotype, suppressible by Ced-12[+]/Ced-1219F3

      (Geisbrecht et al., 2008)

      Ced-12UAS.cGa, Scer\GAL4Mef2.PR, mbcUAS.cBa has eye phenotype, suppressible by mbcD11.2/mbc[+]

      (Geisbrecht et al., 2008)

      Ced-12UAS.cGa, Scer\GAL4Mef2.PR, mbcUAS.cBa has eye phenotype, suppressible by Rac1J11/Rac2Δ/Rac2[+]/Rac1[+]

      (Geisbrecht et al., 2008)
      NOT suppressed by
      Statement
      Reference

      Ced-12UAS.cGa, Scer\GAL4Mef2.PR, mbcUAS.cBa has visceral muscle fiber | embryonic stage phenotype, non-suppressible by msk4/msk[+]

      (Liu et al., 2013)

      Ced-12UAS.cGa, Scer\GAL4Mef2.PR, mbcUAS.cBa has tendon cell | embryonic stage phenotype, non-suppressible by msk4/msk[+]

      (Liu et al., 2013)
      Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Ced-12Scer\UAS.cGa and mbcScer\UAS.cBa via Scer\GAL4Mef2.PR results in prevalent myoblast fusion, muscle attachment, and tendon cell identity phenotypes in embryos. The muscle attachment and tendon cell phenotypes are largely rescued in a Rac1J11/+, Rac2Δ/+ background, but not in a msk4/+ background.

      Expression of Ced-12Scer\UAS.cGa together with mbcScer\UAS.cBa via Scer\GAL4Mef2.PR partially rescues the msk4 embryonic muscle detachment phenotype.

      (Liu et al., 2013)

      Co-expression of Ced-12Scer\UAS.cGa and mbcScer\UAS.cBa using Scer\GAL4Mef2.PR results in missing muscles and many unfused myoblasts.

      Co-expression of Ced-12Scer\UAS.cGa and mbcScer\UAS.cBa using Scer\GAL4GMR.PU causes a rough eye phenotype.

      The rough eye phenotype resulting from Scer\GAL4GMR.PU-mediated expression of Ced-12Scer\UAS.cGa and mbcScer\UAS.cBa is suppressed by heterozygosity for Ced-1219F3, mbcD11.2 or Rac1J11, Rac2Δ.

      (Geisbrecht et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mbcScer\UAS.cBa
      mbcUAS.cBa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Balagopalan
      Secondary FlyBase IDs
        References (4)