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General Information
Symbol
Dmel\Zfrp8GL00541
Species
D. melanogaster
Name
FlyBase ID
FBal0266241
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GL00541
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Zfrp8GL00541 under the control of Scer\GAL4nos.PU results in morphological defects in the ovary.

Expression of Zfrp8GL00541 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 results in ovarian defects that increase in severity with age. The organisation of the germarium is almost normal in females less than 2 days old, and contains germline stem cells that give rise to a few egg chambers. Ovarioles of 7-10 day old females either contain a large cyst of cells instead of an organised germarium and egg chambers or contain ovarioles that have lost most or all of the germline cells. The spectrosomes of the mutant germline stem cells are often replaced by a fusome-like structure.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

Scer\GAL4nos.PU, Zfrp8GL00541 has ovary | adult stage phenotype, enhanceable by RpS2[+]/RpS2P

Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

RpS2P/+ or RpS2PRW1/+ enhances the ovary defects of flies expressing Zfrp8GL00541 under the control of Scer\GAL4nos.PU.

Xenogenetic Interactions
Statement
Reference

Co-expression of Hsap\PDCD2Scer\UAS.P\T.T:Avic\GFP-EGFP suppresses the ovarian defects caused by expression of Zfrp8GL00541 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Zfrp8GL00541
Name Synonyms
Secondary FlyBase IDs
    References (4)