FlyBase Allele Report: Dmel\Atg17[HMS01611]

General Information

Symbol

Dmel\Atg17^HMS01611

Species

D. melanogaster

Name

FlyBase ID

FBal0266518

Feature type

allele

Associated gene

Dmel\Atg17

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01611}

Also Known As

UAS-RNAi-Atg17, UAS-Atg17^RNAi, FIP200 RNAi, UAS-IR-FIP200^HMS01611

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS01611}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01611

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Cunningham et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Kim et al., 2013)

abnormal size | P-stage, with Scer\GAL4^NP0001

(Xu et al., 2015)

abnormal starvation stress response | larval stage, with Scer\GAL4^Cg.PU

(Xu et al., 2015)

decreased cell death | P-stage, with Scer\GAL4^NP0001

(Xu et al., 2015)

increased mortality | larval stage | conditional, with Scer\GAL4^btl.PS

(Valko et al., 2022)

increased mortality | larval stage | conditional, with Scer\GAL4^da.G32

(Valko et al., 2022)

increased mortality | larval stage | conditional, with Scer\GAL4^elav-C155

(Valko et al., 2022)

increased mortality | larval stage | conditional, with Scer\GAL4^fkh.PH

(Valko et al., 2022)

increased mortality | larval stage | conditional, with Scer\GAL4^Mef2.PR

(Valko et al., 2022)

increased mortality | larval stage | conditional, with Scer\GAL4^ppl.PP

(Valko et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Atg17^HMS01611 under the control of Scer\GAL4^{Myo31DF-NP0001} results in significantly delayed midgut degradation after pupariation, with increased size of the midgut and gastric caeca 4 hrs after puparium formation, and decreased autophagy 2 hrs after puparium formation, as compared to controls.

Expression of Atg17^HMS01611 under the control of Scer\GAL4^cg.PU results in a decrease in starvation-induced autophagy in the larval fat body, as compared to controls.

(Xu et al., 2015)

The clearance of the paternal mitochondrial derivatives is mildly delayed in embryos derived from females expressing Atg17^HMS01611 under the simultaneous control of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}.

(Politi et al., 2014)

Animals expressing Atg17^HMS01611 under the control of Scer\GAL4^{elav.Switch.PO} only during the adult stage (after RU486 feeding) show reduced climbing ability in a negative geotaxis assay.

(Kim et al., 2013)

Expression of Atg17^HMS01611 under the control of Scer\GAL4^Mef2.PR is able to significantly suppress the formation of autophagosomes in the muscles of chloroquine-treated larvae starved on low-nutrient food for 6 hours.

(Zirin et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Atg17^HMS01611, Scer\GAL4^GMR.PU is a suppressor of increased cell death | third instar larval stage phenotype of Atg1^UAS.Tag:MYC, Scer\GAL4^GMR.PU

(Kim et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Atg17^HMS01611, Scer\GAL4^GMR.PU is a suppressor of eye disc phenotype of Atg1^UAS.Tag:MYC, Scer\GAL4^GMR.PU

(Kim et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Atg17^HMS01611 almost completely suppresses the accumulation of acidic vesicles and increased cell death seen posterior to the morphogenetic furrow in the eye discs of larvae expressing Atg1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PU.

(Kim et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^da.G32/Atg17^HMS01611 rescues Atg17^3F5

(Kim et al., 2013)

Scer\GAL4^da.G32/Atg17^HMS01611 rescues Atg17^4G7

(Kim et al., 2013)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36918

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01611}attP2/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Atg17^HMS01611

CG1347^HMS01611

fip200^shR

(Politi et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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