FB2025_05 , released December 11, 2025
Allele: Dmel\Atg173F5
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General Information
Symbol
Dmel\Atg173F5
Species
D. melanogaster
Name
FlyBase ID
FBal0288225
Feature type
allele
Associated gene
Dmel\Atg17
Associated Insertion(s)
Carried in Construct
Also Known As
Fip2003F5
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Kim et al., 2013)
Mutagen
Delta2-3 transposase
(Kim et al., 2013)
Progenitor genotype
P{EPgy2}Atg17EY03045
(Kim et al., 2013)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes the Atg17 translation initiation site and more than 50% of the coding sequence.

(Kim et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:5,670,815..5,678,185 [+]
Comment:

A 7371 bp deletion resulting from the imprecise excision of P{EPgy2}Atg17EY03045 that removes most of the Atg17 coding sequence.

(Kim and Lee, 2017.2.21)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  germ cell cancer
      modeled by bamΔ86
      (Zhao et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants progress well into pupal stage P15 (pharate adult stage) but they mostly die during or before eclosion. Mutants manually removed from the puparium have uncoordinated leg movements.

      Atg17MI01469/Atg173F5 adults have an abnormal wing posture and severely reduced climbing ability in a negative geotaxis assay. The brains of Atg17MI01469/Atg173F5 adults have a dramatically reduced number of autophagosomes compared to controls.

      The axonal projection of photoreceptor neurons during brain development is normal in mutant animals.

      Fat bodies and salivary glands of mutant third instar larvae almost completely lack the acidic vesicles and autophagosomes that normally accumulate in wild-type controls. In addition, the mutant larvae are defective in starvation-induced autophagy.

      (Kim et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Atg17MI01469

      (Kim et al., 2013)
      Rescued by

      Atg174G7/Atg173F5 is rescued by Atg17UAS.Tag:FLAG/Scer\GAL4hs.PU

      (Kim et al., 2013)

      Atg173F5 is rescued by Scer\GAL4da.G32/Atg17HMS01611

      (Kim et al., 2013)
      Comments

      Expression of Atg17Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4hs.PU restores developmental autophagy in Atg173F5/Atg174G7 animals.

      (Kim et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Atg173F5
      (Kim and Lee, 2017.2.21)
      FIP2003F5
      (Murakawa et al., 2022, Murakawa et al., 2020, Kuhn et al., 2015)
      FIP2003FG
      (Murakawa et al., 2020)
      Fip2003F5
      (Zhao et al., 2018, Kim et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)