FlyBase Allele Report: Dmel\Egfr[JF02283]

General Information

Symbol

Dmel\Egfr^JF02283

Species

D. melanogaster

Name

FlyBase ID

FBal0266602

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02283}

Also Known As

egfr^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.JF02283}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02283

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates lung adenocarcinoma

modeled by Hsap\KIF5B::Hsap\RET^UAS.cDa

(Das and Cagan, 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^GMR84B12

(Hernández et al., 2015)

abnormal neuroanatomy, with Scer\GAL4^GMR93G07

(Hernández et al., 2015)

Phenotype Manifest In

embryonic/larval frontal nerve, with Scer\GAL4^GMR84B12

(Hernández et al., 2015)

embryonic/larval frontal nerve, with Scer\GAL4^GMR93G07

(Hernández et al., 2015)

embryonic/larval recurrent nerve, with Scer\GAL4^GMR84B12

(Hernández et al., 2015)

embryonic/larval recurrent nerve, with Scer\GAL4^GMR93G07

(Hernández et al., 2015)

Detailed Description

Statement

Reference

Expression of Egfr^JF02283 under the control of either Scer\GAL4^GMR93G07 or Scer\GAL4^GMR84B12 results in frequent loss or reduction of the frontal nerve and disruption of the recurrent nerve.

(Hernández et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Egfr^JF02283, Scer\GAL4^ptc.PU is a suppressor of visible | adult stage phenotype of Hsap\KIF5B::Hsap\RET^UAS.cDa, Scer\GAL4^ptc.PU

(Das and Cagan, 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Egfr^JF02283, Scer\GAL4^ptc.PU is a suppressor of wing vein | ectopic phenotype of Hsap\KIF5B::Hsap\RET^UAS.cDa, Scer\GAL4^ptc.PU

(Das and Cagan, 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36770

y¹ v¹; P{TRiP.JF02283}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Egfr^JF02283

egfr^RNAi

(Matzat et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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