FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\brp5.45
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General Information
Symbol
Dmel\brp5.45
Species
D. melanogaster
Name
FlyBase ID
FBal0266720
Feature type
allele
Associated gene
Dmel\brp
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Fouquet et al., 2009)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?867term.

(Fouquet et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,533,874..9,533,874 [+]
Nucleotide change:

C9533874T

Amino acid change:

Q867term | brp-PD; Q867term | brp-PE; Q913term | brp-PG; Q867term | brp-PH; Q524term | brp-PI; Q1365term | brp-PJ; Q834term | brp-PK; Q908term | brp-PL; Q625term | brp-PM; Q1370term | brp-PN; Q804term | brp-PO; Q920term | brp-PP; Q922term | brp-PQ; Q909term | brp-PR

Reported amino acid change:

?867term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Fouquet et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      brp5.45 mutants exhibit significantly reduced survival rates and motor abilities.

      In brp5.45 mutants, with poorly clustered Ca[2+] channels, the EPSC amplitudes are reduced to approximately 10% of control amplitudes, The amplitude of miniature EPSCs is not significantly affected.

      Depression decay during paired-pulse stimulation is stronger in brp5.45 mutants, compared to controls. Consistent with the altered paired-pulse ratio, the amplitude of the second EPSC in the train is also significantly reduced.

      brp5.45 mutant synapses display enhanced depression during sustained high frequency transmission. Consistently, both the first and second components of recovery are slower.

      (Hallermann et al., 2010)

      T bars are missing at the neuromuscular junction in mutant third instar larvae.

      (Fouquet et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      brp5.45
      (Peled et al., 2014)
      brp5.45
      (Hallermann et al., 2010, Fouquet et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)