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General Information
Symbol
Dmel\His3HisGU.wt
Species
D. melanogaster
Name
FlyBase ID
FBal0266780
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Wild-type His3 gene in the context of a histone gene repeat unit.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The sensory bristles in Df(2L)HisC 4xM{3xHisGU.wt} mutant flies appear indistinguishable from controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Df(2L)HisC, His4rΔ double homozygotes rescued by 12x copies of the HisGU gene unit (bearing His1HisGU.wt, His2AHisGU.wt, His2BHisGU.wt, His3HisGU.wt and His4HisGU.wt) are semi-lethal and adults are fertile and show normal lifespan.

Epidermal Df(2L)HisC clones in His4rΔ homozygotes that also express variants of the HisGU gene unit (12 copies; bearing His1HisGU.wt, His2AHisGU.wt, His2BHisGU.wt and His3HisGU.wt with either His4HisGU.wt, His4HisGU.H4K16R, His4HisGU.H4K16Q or His4HisGU.H4K16A) are able to form normal-looking adult structures with sensory bristles.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

12 copies of a histone repeat unit (flies contain 4 copies of PBac{3xHisGU.wt}) largely rescues the embryonic lethality of Df(2L)HisC homozygotes to adulthood (some pupal lethality is seen).

12 copies of a histone repeat unit (flies contain 4 copies of PBac{3xHisGU.wt}) rescue the severe growth defect seen in homozygous Df(2L)HisC clones in the wing disc.

Clones containing Df(2L)HisC mutant cells stop proliferating, but this phenotype is rescued in animals that also carry four copies of M{3xHisGU.wt}.

Increasing copy numbers of the histone gene repeat unit provided by transgenic constructs can rescue the Df(2L)HisC phenotype: Df(2L)HisC homozygotes that are also homozygous for M{1xHisGU.wt} develop a defective cuticle. Df(2L)HisC homozygotes that are also homozygous for M{3xHisGU.wt} develop a wild-type cuticle pattern but fail to hatch. Df(2L)HisC homozygotes that carry four copies of M{3xHisGU.wt} (homozygous for two different insertions of M{3xHisGU.wt}) are rescued to become fertile adults with no visible morphological defects.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
His3HisGU.wt
Name Synonyms
Secondary FlyBase IDs
    References (7)