FlyBase Allele Report: Dmel\Toll-7[UAS.cYa]

General Information

Symbol

Dmel\Toll-7^UAS.cYa

Species

D. melanogaster

Name

FlyBase ID

FBal0267033

Feature type

allele

Associated gene

Dmel\Toll-7

Associated Insertion(s)

Carried in Construct

P{UAS-Toll-7.Y}

Also Known As

UAS-Toll-7

Key Links

Transgenic product class

wild_type

(Yagi et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Yagi et al., 2010)

Mutagen

in vitro construct

(Yagi et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-Toll-7.Y}

Cytology

Description

UASt regulatory sequences drive expression of Toll-7 coding sequences.

(Yagi et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Toll-7

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^AM29

(Ward et al., 2015)

lethal, with Scer\GAL4^e22c

(Yagi et al., 2010)

lethal, with Scer\GAL4^ptc-559.1

(Yagi et al., 2010)

Phenotype Manifest In

adult abdomen, with Scer\GAL4^32B

(Yagi et al., 2010)

adult abdomen, with Scer\GAL4^da.G32

(Yagi et al., 2010)

adult olfactory receptor neuron Or67a, with Scer\GAL4^AM29

(Ward et al., 2015)

eye, with Scer\GAL4^da.G32

(Yagi et al., 2010)

eye, with Scer\GAL4^GMR.PF

(Yagi et al., 2010)

eye, with Scer\GAL4^lz-gal4

(Yagi et al., 2010)

leg, with Scer\GAL4^dpp.PS

(Yagi et al., 2010)

leg disc, with Scer\GAL4^dpp.PS

(Yagi et al., 2010)

macrochaeta | ectopic, with Scer\GAL4^71B

(Yagi et al., 2010)

macrochaeta | ectopic, with Scer\GAL4^da.G32

(Yagi et al., 2010)

wing, with Scer\GAL4^dpp.PS

(Yagi et al., 2010)

wing disc, with Scer\GAL4^dpp.PS

(Yagi et al., 2010)

wing vein, with Scer\GAL4^da.G32

(Yagi et al., 2010)

Detailed Description

Statement

Reference

Expression of Toll-7^Scer\UAS.cYa under the control of Scer\GAL4^AM29 results in a severe lateral mistargeting of DM6 olfactory neuron axons to the Toll-7-expressing region. Targeting of DL4 olfactory neuron axons is unaffected.

Expression of Toll-7^Scer\UAS.cYa under the control of Scer\GAL4^AM29 in homozygous Df(2R)Toll-7^AW1 animals results in lateral mistargeting of DM6 olfactory receptor neuron axons. These mistargeted axons intermingle extensively with Scer\GAL4^Mz19-positive projection neuron dendrites.

(Ward et al., 2015)

Compared with wild-type, flies overexpressing Scer\GAL4^hs.PU>Toll-7^Scer\UAS.cYa show moderately enhanced survival after infection with Rift Valley Fever Virus (RVFV).

(Moy et al., 2014)

Expression of Toll-7^Scer\UAS.cYa under the control of Scer\GAL4^da.G32 results in mild defects in abdominal closure, extra bristles, rough eyes and wing vein thickening. The penetrance of the rough eye phenotype is close to 100% while the penetrance of other phenotypes is approximately 5-10%.

Expression of Toll-7^Scer\UAS.cYa under the control of Scer\GAL4^32B results in mild defects in an abdominal closure defect, extra bristles and a rough eye phenotype.

Expression of Toll-7^Scer\UAS.cYa under the control of Scer\GAL4^71B generates an extra bristle phenotype.

Expression of Toll-7^Scer\UAS.cYa under the control of Scer\GAL4^dpp.PS generates a mild bifurcated wing phenotype, with a split occurring at the distal end of the wing along the anterior-posterior boundary, along with a leg defect phenotype. This defect can be traced to the imaginal disc stage, where abnormal folding at the anterior-posterior boundary is found.

Expression of Toll-7^Scer\UAS.cYa under the control of either Scer\GAL4^GMR.PF or Scer\GAL4^lz-gal4 results in a rough eye phenotype.

(Yagi et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Toll-7^UAS.cYa/Scer\GAL4^Mz19 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Toll-6^ex13

(Ward et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Toll-7^UAS.cYa/Scer\GAL4^Mz19 is a suppressor of adult olfactory receptor neuron Or88a phenotype of Toll-6^ex13

(Ward et al., 2015)

Toll-7^UAS.cYa/Scer\GAL4^Mz19 is a suppressor of adult antennal lobe projection neuron VA1d adPN | somatic clone phenotype of Toll-6^ex13

(Ward et al., 2015)

Toll-7^UAS.cYa/Scer\GAL4^Mz19 is a suppressor of adult antennal lobe projection neuron DC3 adPN | somatic clone phenotype of Toll-6^ex13

(Ward et al., 2015)

Toll-7^UAS.cYa/Scer\GAL4^Mz19 is a suppressor of dendrite | somatic clone phenotype of Toll-6^ex13

(Ward et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Toll-7^Scer\UAS.cYa under the control of Scer\GAL4^Mz19 rescues the VA1d olfactory receptor neuron axon targeting defects seen in Toll-6^ex13 mutants.

Expression of Toll-7^Scer\UAS.cYa under the control of Scer\GAL4^Mz19 also rescues the mistargeting of VA1d and DC3 projection neuron dendrites which is seen in Toll-6^ex13 adNb clones.

Expression of Toll-7^Scer\UAS.cYa under the control of Scer\GAL4^AM29 in homozygous Df(2R)Toll-7^AW1 animals results in extensive intermingling of mistargeted DM6 olfactory receptor neuron axons with Scer\GAL4^Mz19-positive projection neuron dendrites. This intermingling is still seen if the flies are also carrying Toll-6^ex13 mutant adNb clones.

(Ward et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^peb-GAL4/Toll-7^UAS.cYa rescues Df(2R)Toll-7^AW1

(Ward et al., 2015)

Comments

Expression of Toll-7^Scer\UAS.cYa under the control of Scer\GAL4^peb-GAL4 rescues the VA1d olfactory receptor neuron targeting defects seen in Df(2R)Toll-7^AW1 mutants.

(Ward et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Toll-7^Scer\UAS.cYa

Toll-7^UAS.cYa

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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