Open Close
General Information
Symbol
Hsap\FMR1UAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0267401
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
pUAS-MYC-hFMR1, UAS-hFMR1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt drives expression of Hsap\FMR1 tagged with Tag:MYC.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of Hsap\FMR1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PU rescues the neuromuscular junction synapse architecture defects seen in Fmr1Δ50M mutant third instar larvae. The increase in Futsch-positive loops is also fully rescued.

Expressing Hsap\FMR1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PU rescues the expanded terminals and supernumerary synaptic boutons seen in the small ventrolateral neurons of Fmr1Δ50M mutant adults.

Expression of Hsap\FMR1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ey-OK107 rescues the decreases in olfactory learning seen in Fmr1Δ50M mutants.

Expression of Hsap\FMR1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155 completely suppresses the synaptic overgrowth defects characterising Fmr1Δ50M mutants.

Expression of Hsap\FMR1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155 fully rescues both the enlarged neuromuscular junctional area and increased synaptic branching that characterise Fmr1Δ50M mutants.

Pre-synaptic expression of Hsap\FMR1Scer\UAS.T:Hsap\MYC using Scer\GAL4elav-C155 completely restores bouton number to control levels in Fmr1Δ50M mutants.

Scer\GAL4elav-C155>Hsap\FMR1Scer\UAS.T:Hsap\MYC can strongly rescue the mini-bouton number in Fmr1Δ50M mutants back to wild-type levels.

Expression of Hsap\FMR1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 completely suppresses the male fecundity phenotype that characterises Fmr1Δ50M mutants.

Expression of Hsap\FMR1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 can fully restore the spermatid axoneme architecture in Fmr1Δ50M mutants.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Hsap\FMR1Scer\UAS.T:Hsap\MYC
Hsap\FMR1UAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (2)