FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Caf1-180270
Open Close
General Information
Symbol
Dmel\Caf1-180270
Species
D. melanogaster
Name
FlyBase ID
FBal0267422
Feature type
allele
Associated gene
Dmel\Caf1-180
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Song et al., 2007)
Mutagen
Delta2-3 transposase
(Song et al., 2007)
Progenitor genotype
P{GT1}BG02681
(Song et al., 2007)
Cytology
Description

Imprecise excision of P{GT1}BG02681 resulting in a 576 bp deletion removing the promoter and the N-terminal portions of the Caf1-180 coding region.

(Song et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:8,605,983..8,606,558 [-]
Comment:

Estimated endpoints of a 576 bp deletion resulting from the imprecise excison of the progenitor insertion.

(Song et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Death of Caf1-180270 hemizygous males occur progressively over the three larval instars, but predominantly during the second instar. Generally, Caf1-180270 mutant larvae are developmentally arrested one or two days prior to their death. Rarely, a few escapers can develop into third instar larvae where they persist up to the 18th day of life. Such arrested larvae appear normal but remain smaller than the wild-type and display a smaller fat body.

      Females carrying Caf1-180270 mutant germline clones are sterile. The ovaries with Caf1-180270 mutant germline clones fail to develop beyond stage 10 of oogenesis.

      Flies with Caf1-180270 mutant clones induced in their eyes display tissue specific abnormalities. While some flies lack eyes completely, others exhibit extremely small eyes with disorganized ommatidia.

      Heterozygous Caf1-180270 suppresses the eye colour and bristle position effect variegation (PEV) phenotypes of In(2)Heidi-P{Winkelried}D and T(2;3)SbV, respectively.

      Heterozygous Caf1-180270 mutants are more sensitive to gamma-irradiation that is known to lead to double-strand DNA breaks. The efficiency of homologous recombination gap repair is also reduced in Caf1-180270 heterozygotes, although not completely abolished.

      (Song et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Caf1-180270/Caf1[+] is an enhancer of sternopleural bristle phenotype of Pc3

      (Song et al., 2007)

      Caf1-180270/Caf1[+] is an enhancer of adult external mesothorax phenotype of Pc3

      (Song et al., 2007)

      Caf1-180270/Caf1[+] is an enhancer of adult external prothorax | ectopic phenotype of Pc3

      (Song et al., 2007)

      Caf1-180270/Caf1[+] is an enhancer of haltere | ectopic phenotype of Pc3

      (Song et al., 2007)

      Caf1-180270/Caf1[+] is an enhancer of wing phenotype of Pc3

      (Song et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of Caf1-180270 enhances the loss-of-sternopleural-bristle and the wing-to-haltere transformation phenotypes of heterozygous Pc3.

      (Song et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Caf1-180270 is rescued by Caf1-180UAS.cSa

      (Song et al., 2007)

      Caf1-180270 is rescued by Caf1-180FRT

      (Song et al., 2007)
      Comments

      Ubiquitous expression of Caf1-180Scer\UAS.cSa under the control of Scer\GAL4ptc-559.1 completely rescues the mutant phenotypes associated with Caf1-180270.

      Caf1-180Scer\FRT rescues the lethality and sterility of Caf1-180270. The rescued animals do not show any visible defects.

      (Song et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Caf1-180270
      (Yee et al., 2019)
      Caf1270
      dCAF-1-p180270
      (Song et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)