FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CoRestGF60
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General Information
Symbol
Dmel\CoRestGF60
Species
D. melanogaster
Name
FlyBase ID
FBal0267495
Feature type
allele
Associated gene
Dmel\CoRest
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Domanitskaya and Schüpbach, 2012)
Mutagen
ethyl methanesulfonate
(Domanitskaya and Schüpbach, 2012)
Progenitor genotype
Cytology
Description

G to A mutation in the first nucleotide of the third intron, resulting in a non-functional splice donor site. RT-PCR analysis shows that the third intron is retained, and the presence of in an in-frame stop codon at the end of the third intron results in a truncated protein, lacking known functional domains. All three splice variants identified are affected by the mutation.

(Domanitskaya and Schüpbach, 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:19,523,435..19,523,435 [+]
Nucleotide change:

G19523435A

Comment:

G to A mutation in the first nucleotide of the third intron, resulting in a non-functional splice donor site.

(Domanitskaya and Schüpbach, 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous posterior follicle cells are smaller and have much smaller nuclei than their neighbouring wild-type cells in mosaic egg chambers. Homozygous follicle cell clones fail to undergo the switch from mitotic cycles to endocycles, with mitotic markers present after stage 6. This proliferation phenotype is more pronounced in the posterior follicle cells.

      (Domanitskaya and Schüpbach, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      CoRest[+]/CoRestGF60 is an enhancer of visible | dominant phenotype of Delta7

      (Domanitskaya and Schüpbach, 2012)
      Other
      Statement
      Reference

      CoRest[+]/CoRestGF60, NXK11 has visible | dominant phenotype

      (Domanitskaya and Schüpbach, 2012)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      CoRest[+]/CoRestGF60 is an enhancer of wing vein phenotype of Delta7

      (Domanitskaya and Schüpbach, 2012)
      Other
      Statement
      Reference

      CoRest[+]/CoRestGF60, NXK11 has wing vein phenotype

      (Domanitskaya and Schüpbach, 2012)

      CoRest[+]/CoRestGF60, NXK11 has wing blade phenotype

      (Domanitskaya and Schüpbach, 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing defects seen in Dl7/+ flies are enhanced by CoRestGF60/+: the extent of thickening and deltas at the wing veins is increased and in some cases severe wing blistering is seen.

      CoRestGF60/NXK11 transheterozygotes show thickened wing veins and deltas. Wing blistering is occasionally seen.

      (Domanitskaya and Schüpbach, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CoRESTGF60
      (Horvath et al., 2016, Domanitskaya and Schüpbach, 2012)
      CoRestGF60
      Name Synonyms
      Secondary FlyBase IDs
        References (2)